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zymogen

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zymogen

 or proenzyme

Any of a class of proteins that are secreted by cells and are inactive precursors of enzymes. Transformation into active enzymes occurs as one or more peptide bonds in the zymogen are cleaved. Examples include trypsinogen and chymotrypsinogen, secreted by the pancreas and converted by proteolysis in the small intestine into the active enzymes trypsin and chymotrypsin; and numerous coagulation factors.


zymogen [′zī·mə·jən]
(biochemistry)
The inactive precursor of an enzyme; liberates an active enzyme on reaction with an appropriate kinose. Also known as proenzyme.


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Measurement of the size distribution of zymogen granules from rat pancreas.
1992) subjected to long fasting showed narrower lumen of excretory ducts and reduced cellular activity, demonstrated by the scarcity of zymogen granules.
Plasminogen is an inactive zymogen, requiring the action of one of the two plasminogen activators, uPA or tPA, to convert it into active plasmin (Irigoyen et al.
 
 
 
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