The test was performed in triplicate and the total coumarin content was expressed as milligrams of coumarin equivalents (1,2-benzopyrone) per gram of the sample extract (mg CE/g) .
Total coumarin contents were estimated in terms of 1,2-benzopyrone equivalents (BPE) which are presented in Table-1.
Amelioration of L-thyroxine-induced hyperthyroidism by coumarin (1,2-benzopyrone
) in female rats.
Youssef, "Synergistic interaction between coumarin 1,2-benzopyrone
and indole-3-butyric acid in stimulating adventitious root formation in Vigna radiata (L.) Wilczek cuttings: I.
Coumarin (1,2-benzopyrone) was previously reported as responsible for some biological activities of this plant species.
The pharmacological effects of Mikania genus are attributed mainly to the presence of coumarin (1,2-benzopyrone) and derivatives.
The Irish melanoma group first reported that a daily ingestion of 50 mg of coumarin (1,2-benzopyrone) or warfarin (4-hydroxycoumarin) prevented the early recurrence of high risk malignant melanoma without toxic effects in man (Thornes et al., 1989, 1994).
These data evidenced the critical role of the prenyloxy chain fixed at C7 of the 1,2-benzopyrone ring in the antiproliferative effect of umbelliprenin and aurapten and, attributed the higher efficacy of umbelliprenin to the replacement of the geranyloxy group of auraptene at C7 by an aliphatic sesquiterpenyloxy group.
Umbelliprenin differs from auraptene by the presence of an acyclic sesquiterpenene group in place of the geranyl group at C7-OH of the 1,2-benzopyrone ring.
1,2-Benzopyrone (coumarin)--substrate and inducer of the murine 7-hydroxylase (Cyp2a-5).
The rarity of liver toxicity in patients treated with coumarin (1,2-benzopyrone).
Treatment of metastatic renal carcinoma with coumarin (1,2-benzopyrone) and cimetidine.