calcitriol

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calcitriol

[‚kal·sə′trī‚ōl]
(biochemistry)
1,25-dihydroxycholecalciferol, the form of vitamin D that is involved in intestinal absorption of Ca2+and Ca2+resorption by bone.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Hammond, "Elevated serum parathyroid hormone related protein and 1,25-dihydroxycholecalciferol in hypercalcaemia associated with adult T-cell leukaemialymphoma," Postgraduate Medical Journal, vol.
DeLuca, "Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine," Proceedings of the National Academy of Sciences of the United States of America, vol.
Abbreviations 25(OH)[D.sub.3]: 25-Hydroxycholecalciferol 1,25-[(OH).sub.2]: 1,25-Dihydroxycholecalciferol [D.sub.3] AS: Ankylosing spondylitis AIDS: Acquired immunodeficiency syndrome BASDAI: Bath Ankylosing Spondylitis Disease Activity Index BASFI: Bath Ankylosing Spondylitis Functional Index BMD: Bone mineral density CRP: C-reactive protein CVD: Cardiovascular diseases DC: Dendritic cells DMARDs: Disease-modifying antirheumatic drugs ESR: Erythrocyte sedimentation rate HLA: Human leukocyte antigen IL: Interleukin IOM: Institute of Medicine MHC: Major histocompatibility complex NSAIDs: Nonsteroidal anti-inflammatory drugs Th: T helper TNF-[alpha]: Tumor necrosis factor alpha TNFi: Tumor necrosis factor inhibitors VDR: Vitamin D receptor.
Vanel et al., "Evidence for persistent vitamin D 1-alpha-hydroxylation in hemodialysis patients: evolution of serum 1,25-dihydroxycholecalciferol after 6 months of 25-hydroxycholecalciferol treatment," Nephron Clinical Practice, vol.
Calcitriol (1,25-dihydroxycholecalciferol) and alfacalcidol (1 alpha hydroxycholecalciferol) are not recommended as they may be associated with hypervitaminosis and hypercalcemia; requiring monitoring of serum calcium when initiated on these supplements [30,32,33].
The effect of dietary cholecalciferol, 25- hydroxycholecalciferol and 1,25-dihydroxycholecalciferol on the development of tibial dyschondroplasia in broiler chickens in the absence and presence of disulfiram.
Active form of vitamin D, i.e., 1,25-dihydroxycholecalciferol, vitamin D3 performs an important role in maintaining calcium homeostasis in the bone, liver, intestine and parathyroid gland [1].
1-hydroxylase found primarily in the kidney resulting in the formation of 1,25-dihydroxycholecalciferol. 1,25 dihydroxy D3 is the most potent vitamin D metabolite.
Cholecalciferol is hydroxylated to 25-hydroxycholecalciferol in the liver; 25-hydroxycholecalciferol is then transformed by the kidneys to the hormonally active metabolite calcitriol, 1,25-dihydroxycholecalciferol (1,25-[(OH).sub.2][D.sub.3]).
1,25-Dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritis.
Effects of phytase and 1,25-dihydroxycholecalciferol on phytate utilization and the quantitative requirement for calcium and phosphorus in young broiler chickens.
Interactions of parathyroid hormone, 25-hydroxycholecalciferol, and 1,25-dihydroxycholecalciferol. N Engl J Med 1981;305(3):117-23.