Quintanilla-Flores et al., "1,25-dihydroxyvitamin D and PTHrP mediated malignant hypercalcemia in a seminoma," BMC Endocrine Disorders, vol.
Raue, "Parathyroid hormone-related protein (PTHrP) does not regulate 1,25-dihydroxyvitamin D serum levels in hypercalcemia of malignancy," Journal of Clinical Endocrinology and Metabolism, vol.
Vitamin D receptors have been isolated in brain, prostate, breast, colon, heart and immune cells and these cells respond directly to 1,25-dihydroxyvitamin D
And make sure that your doctor orders a test for 25-hydroxyvitamin D, not 1,25-dihydroxyvitamin D
, which is the active form.
Analyte Patient result Reference interval Calcium 9.8 mg/dL 8.5-10.5 mg/dL (2.4 mmol/L) (2.1-2.6 mmol/L) Intact PTH 68 pg/mL 10-65 pg/mL (7.2 pmol/L) (1.1-6.8 pmol/L) Phosphorus 5.1 mg/dL 2.5-4.5 mg/dL (1.6 mmol/L) (0.8-1.5 mmol/L) [4.3-6.3 mg/dL (1.4-2.0 mmol/L)] (a) 25-Hydroxyvitamin D 13 [micro]g/mL 30-80 [micro]g/mL 1,25-Dihydroxyvitamin D
89 ng/L 15-75 ng/L (a) Interval age adjusted for 3 years.
Assay of circulating 1,25-dihydroxyvitamin D
involving a novel single-cartridge extraction and purification procedure.
The active form of vitamin D, 1,25-dihydroxyvitamin D
, is made in many different tissues, including colon, prostate, and breast.
25-Hydroxyvitamin D (25-OH-vitamin D) and 1,25-dihydroxyvitamin D
have important effects on calcium absorption, bone calcium balance, and renal excretion of calcium and phosphorus (1).
The available data show that Sr absorption is increased by therapeutic administration of 1,25-dihydroxyvitamin D
or renal activation of 25-hydroxyvitamin D-1a-hydroxylase [14, 15].
We prospectively examined the relationship between plasma levels of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D
[1,25(OH)2D] and risk of breast cancer in a case-control study nested within the Nurses' Health Study cohort.