naphthol

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naphthol

naphthol (năfˈthôl), C10H7OH, either of two crystalline monohydric alcohols. The naphthols are position isomers, differing in the location of the hydroxyl group, –OH, on the carbon skeleton of naphthalene; α-naphthol is 1-hydroxynaphthalene and β-naphthol is 2-hydroxynaphthalene: The naphthols have a number of similar properties. They melt at 95℃ and 122℃ and boil at 279℃ and 285℃, respectively; both are soluble in alcohol and ether and slightly soluble in hot water. One way in which they differ is the form of their crystals—α-naphthol crystallizes in prisms and β-naphthol in plates. The naphthols are prepared by reacting naphthalene with sulfuric acid and hydrolyzing the resultant sulfate ester by heating it with sodium hydroxide solution. Both naphthols exhibit antiseptic properties. They are used in the synthesis of certain azo dyes and antioxidants for rubbers. Naphthol solutions are used in chemical analysis to detect the ferric ion; dissolved ferric ion turns an α-naphthol solution violet and turns a β-naphthol solution green.

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There is evidence that 1-naphthol and 2-naphthol act as EDCs through thyroid hormone receptor antagonist activity (Sun et al.
1-naphthyl phosphatase, 1-naphthol, ethylenediaminetetraacetic acid, bovine serum albumin (BSA), nitro blue tetrazolium and Tween 20 were obtained from Sigma Chemical Co.
The retention times (RT) obtained for the control red dye 40, standard 1-naphthol, standard aniline and the studied samples are shown in tables 1 and 2.
Phenylphosphorodichloridate (PPDC), biphenylphosphorodichlondate, and naphthylphosphorodichloridate were prepared from phenol, 1-naphthol, and 4-phenylphenol, respectively, with phosphorusoxychloride using procedure reported elsewhere [41]
1-Naphthol and 2-naphthol, which can devolve from naphthalene, were moderately correlated (rho = 0.40 and 0.55 within the first and second prenatal samples, respectively; p < 0.01).Similarly, in NHANES, 2,4,6-TCP and TCPy (rho = 0.55) and 2,4-DCP and 2,5-DCP (rho = 0.53) were strongly correlated (p < 0.01).
4 and 5 show the response curves of 4 p nitro phenyl-azo- 1-naphthol solutions containing different dye concentrations as a change in the optical density (DA) at 625 nm and 472 nm respectively, against the absorbed dose [DA = Adeg-Ai], Where Adeg and Ai are optical densities before and after irradiation.
Human exposure to naphthalene is nearly universal; the recent National Health and Nutrition Examination Survey studies demonstrated detectable levels of 1-naphthol glucuronide in the urine of all 2,785 subjects tested (Li et al.
For example, 1-naphthol is a metabolite of both naphthalene (used as a moth repellent and also a polycyclic aromatic hydrocarbon from combustion processes) and carbaryl (Shealy et al.
Our results show that both inhalation exposure and smoking significantly contributed to urinary 1-naphthol levels.
Recently, the CDC reported measurable levels of urinary 3,5,6-trichloro-2-pyridinol (TCPY), a metabolite of chlorpyrifos and chlorpyrifosmethyl, and 1-naphthol (1N), a metabolite of carbatyl and naphthalene, in > 90% and 75% of males in the United States, respectively (CDC 2003).
Naphthalene ([greater than or equal to] 99%, scintillation grade), [[sup.2][H.sub.8]]naphthalene ([greater than or equal to] 98 atom% D), 1-naphthol ([greater than or equal to] 99%), 2-naphthol ([greater than or equal to] 99%), [[sup.2][H.sub.7]] 1-naphthol (97 atom% D), [[sup.2][H.sub.6]]benzene, and methanol (purge and trap grade) were obtained from Aldrich Chemical Co.