Deoxycorticosterone

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deoxycorticosterone

[dē¦äk·sē‚kȯrd·ə′kä·stə‚rōn]
(biochemistry)
C21H30O3 A steroid hormone secreted in small amounts by the adrenal cortex.

Deoxycorticosterone

 

(also cortexone), an intermediate product in the biosynthesis of hormones of the adrenal cortex. Formed primarily from progesterone, it is a mineralocorticoid, that is, an active regulator of mineral metabolism, and in this connection the most stable preparation of deoxycorticosterone is deoxycorticosterone acetate, which is used in medicine.

References in periodicals archive ?
Among the 15 steroids in the panel, 11-deoxycortisol and 11-deoxycorticosterone were the only 2 that were consistently higher (P < 0.0001) in all subtypes ofCS than in groups without CS.
Knockdown of Dicer1 significantly increased secreted levels of cortisol (1.33 [+ or -] 0.11fold; p = 0.01), corticosterone (1.32 [+ or -] 0.13-fold; p = 0.03), 11-deoxycorticosterone (1.53 [+ or -] 0.09-fold; p <0.001), 18- hydroxycorticosterone (1.29 [+ or -] 0.10-fold; p = 0.04), and aldosterone (1.47 [+ or -] 0.11-fold; p <0.01) relative to scrambled siRNA transfected cells.
Purified CYP11B2 catalyzed the multi-hydroxylation reactions of the substrate (11-deoxycorticosterone) giving corticosterone, 18-hydroxydeoxycorticosterone, 18-hydroxycorticosterone, and significant amount of aldosterone as products, while purified CYP11B1 catalyzed only 11[beta]- and 18-hydroxylations of the same substrate to yield corticosterone and 18-hydroxydeoxycorticosterone, respectively (refer to Fig.
All core clinical biochemistry and hormonal tests were performed at Royal Hospital, Oman, using Architect 8000c and Architect 2000i, respectively, with Automated Processing System (Abbott, USA); and 17[alpha]-hydroxyprogesterone, renin and aldosterone were performed by ELISA (DRG, USA); while 11-deoxycortisol, 11-deoxycorticosterone, corticosterone, androstenedione and ACTH were performed at Laboratoroire Cerba (France).
As measured by HPLC, corticosterone and 11-deoxycorticosterone secretion to the medium increased linearly for at least 24 hr.
We have tentatively identified 11-deoxycorticosterone, androstadienedione, and androstenedione in the effluent.
Androstenedione, cortisone, 11-deoxycortisol, 21-deoxycortisol, 11-deoxycorticosterone, pregnenolone, 17-hydroxyprogesterone, and 17-hydroxypregenenolone were from Steraloids.
Compared to normal female individuals, female carriers for 21-OHD frequently demonstrate an increased secretion of the 21-OH precursors 17-hydroxyprogesterone (17-OHP) and progesterone (P4) [35-43] and lower levels of 11-deoxycorticosterone [37] as expected.
Beginning from 11-deoxycorticosterone in the zona glomerulosa of the adrenal cortex, aldosterone synthase catalyzes the sequential activities of 11[beta]-hydroxylase, 18-hydroxylase, and, finally, 18-methyl oxidase, the final three steps in aldosterone synthesis (1,2).
We measured 15 adrenal steroids simultaneously by LCMS/MS, including aldosterone, cortisol, 18-oxocortisol, 18-hydroxycortisol, cortisone, 11-deoxycortisol, 21deoxycortisol, corticosterone, 11-deoxycorticosterone, progesterone, 17-hydroxyprogesterone, pregnenolone, androstenedione, dehydroepiandrosterone (DHEA), and DHEA-sulfate (DHEA-S).
The accumulation of 11-deoxycorticosterone and its metabolites causes hypertension in about two-thirds of these patients.
Deficiency of 21-hydroxylase prevents the conversion of 17-hydroxyprogesterone to 11-deoxycorticosterone, leading to excessive production of androgens, which ultimately affects several stages of growth and development (4).