Deoxycorticosterone

(redirected from 11-deoxycorticosterone)
Also found in: Dictionary, Medical.

deoxycorticosterone

[dē¦äk·sē‚kȯrd·ə′kä·stə‚rōn]
(biochemistry)
C21H30O3 A steroid hormone secreted in small amounts by the adrenal cortex.

Deoxycorticosterone

 

(also cortexone), an intermediate product in the biosynthesis of hormones of the adrenal cortex. Formed primarily from progesterone, it is a mineralocorticoid, that is, an active regulator of mineral metabolism, and in this connection the most stable preparation of deoxycorticosterone is deoxycorticosterone acetate, which is used in medicine.

References in periodicals archive ?
Accumulation of these substrates, pregnenolone and progesterone will enhance the 21-hydroxylation and 11 [beta]-hydroxylation steps in the mineralocorticoid pathway resulting in an overproduction of 11-deoxycorticosterone and corticosterone.
Most important are the pathways through which orally administered progesterone is transformed into 11-deoxycorticosterone (DOC) and further into the metabolites that form pregnanolone (3[alpha],-hydroxy-5[alpha]-pregnane-20-one) and its isomer allopregnanolone (3[beta]-20[beta]-dihydroxy-5[alpha]-pregnane).
As measured by HPLC, corticosterone and 11-deoxycorticosterone secretion to the medium increased linearly for at least 24 hr.
We have tentatively identified 11-deoxycorticosterone, androstadienedione, and androstenedione in the effluent.
Deficiency of 21-hydroxylase prevents the conversion of 17-hydroxyprogesterone to 11-deoxycorticosterone, leading to excessive production of androgens, which ultimately affects several stages of growth and development (4).
Simultaneous radioimmunoassay of plasma aldosterone, corticosterone, 11-deoxycorticosterone, progesterone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol and cortisone.
Deficiency in the CYP21 gene prevents the conversion of 17-hydroxyprogesterone to 11-deoxycorticosterone, leading to an excessive production of androgen, which in turn affects several stages of growth and development (1).