Zou, "Chemical synthesis and characterization of conducting poly(2-Aminothiazole
)," Materials Science Forum, vol.
scaffold has played an important role in medicinal chemistry and drug discovery research.
Determination of Hg in water by CVAAS using 2-aminothiazole
Norris et al., "2-Aminothiazole
as a novel kinase inhibitor template.
 have found that Schiff bases derived from 2-aminothiazole
exhibit antibacterial, antifungal and anti- inflammatory activities.
Here we are interested to study newly synthetized aminothiazoles, especially 2-aminothiazole
derivatives which represent a class of heterocyclic ring system possessing antiviral , antimicrobial , anticancer , and anti-inflammatory activities .
In view of the importance of 2-aminothiazole
and its derivatives, several methods were reported in the literature.
In these cases targeted compounds were obtained by cyclization of 2-aminothiazole
derivatives with bis(methylthio)methylene malononitrile , benzylidene malononitrile , 2-acetylbutyrolactone , and formamide and formic acid .
Keywords: Multidrug resistance, Drug development, 2-Aminothiazole
, Acylation of 2-aminothiazole
, Antimicrobial activity.
Synthesis of 2-aminothiazoles
and 2-thiazolecarboxamides with Anti-Anoxic Activity.
and their derivatives are well-known because of their wide spectrum of biological activity shown by the thiazole moiety [3-6].
and their derivatives have been used as pioneers for the synthesis of biologically active molecules [1-4].