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McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



3,4-dihydroxyphenylalanine, C6H3(OH)2CH2CH(NH2)COOH, an amino acid.

In animals, dopa is one of the precursors in the chain of catecholamine biosynthesis. It is produced in tissues by the oxidation of tyrosine. In animals, plants, and some microorganisms, dopa is the first intermediate product in the synthesis of melanins. Healthy persons excrete from 50 to 55 μg of dopa daily with the urine; the amount increases in the presence of a neuroblastoma, a kind of malignant tumor. An inhibitor of dopa decarboxylase, a-methyldopa (Aldomet), is used in the treatment of parkinsonism and hypertension.


Matlina, E. Sh., and V. V. Men’shikov. Klinicheskaia biokhimiia katekholaminov. Moscow, 1967.
Grollman, A. Klinicheskaia endokrinologiia i ee fiziologicheskie osnovy. Moscow, 1969. (Translated from English.)
The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Zebra mussel byssal threads are fibrous extracellular structures composed largely of proteins, many of which contain the post-translationally modified amino acid 3,4-dihydroxyphenylalanine (Dopa) (Rzepecki and Waite, 1993).
Simultaneous determination of acidic 3,4-dihydroxyphenylalanine metabolites and 5-hydroxyindole-3-acetic acid in urine by high-performance liquid chromatography.
A major component, foot protein 1 (fp-1), is an adhesive 130-kDa protein containing a high proportion of 3,4-dihydroxyphenylalanine (DOPA) residues (Waite and Tanzer, 1981; Waite, 1983).
Simultaneous assay of 3,4-dihydroxyphenylalanine catecholamines O-methylated metabolites in human plasma using high-performance liquid chromatography.
Two types of polyphenolic proteins, foot proteins I and 2, both of which incorporate 3,4-dihydroxyphenylalanine (DOPA) into their primary structures, have been isolated from the mussel Mytilus edulis, and characterized (see Waite, 1992, for a review).
Total and non-protein-bound fractions of 3,4-dihydroxyphenylalanine [Letter].
Several analytical methods for the determination of plasma 3,4-dihydroxyphenylalanine (L-DOPA) by HPLC have been reported.
Perucca Total and Non-Protein-bound Fractions of 3,4-Dihydroxyphenylalanine Clin.

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