Dopa

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dopa

[′dō·pə]
(biochemistry)

Dopa

 

3,4-dihydroxyphenylalanine, C6H3(OH)2CH2CH(NH2)COOH, an amino acid.

In animals, dopa is one of the precursors in the chain of catecholamine biosynthesis. It is produced in tissues by the oxidation of tyrosine. In animals, plants, and some microorganisms, dopa is the first intermediate product in the synthesis of melanins. Healthy persons excrete from 50 to 55 μg of dopa daily with the urine; the amount increases in the presence of a neuroblastoma, a kind of malignant tumor. An inhibitor of dopa decarboxylase, a-methyldopa (Aldomet), is used in the treatment of parkinsonism and hypertension.

REFERENCES

Matlina, E. Sh., and V. V. Men’shikov. Klinicheskaia biokhimiia katekholaminov. Moscow, 1967.
Grollman, A. Klinicheskaia endokrinologiia i ee fiziologicheskie osnovy. Moscow, 1969. (Translated from English.)
References in periodicals archive ?
These include neuroactive substances such as [gamma]-aminobutyric acid (GABA), 3,4-dihydroxyphenylalanine (DOPA), catecholamines, and choline derivatives, organic and inorganic compounds, and the inorganic ions [Mg.
In the body, the rate of 3,4-dihydroxyphenylalanine (DOPA) formation by autooxidation of tyrosine was found to be negligible compared with the rate of formation by enzymatic catalysis.
The responses of the larvae to the neuroactive compounds 3,4-dihydroxyphenylalanine (DOPA, 1-100 [[micro]molar]), epinephrine (EP, 1 [[micro]molar]), [Gamma]-aminobutyric acid (GABA, 0.
Zebra mussel byssal threads are fibrous extracellular structures composed largely of proteins, many of which contain the post-translationally modified amino acid 3,4-dihydroxyphenylalanine (Dopa) (Rzepecki and Waite, 1993).

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