3-methylindole


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3-methylindole

[¦thrē meth·ə′lin‚dōl]
(organic chemistry)
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The expression of the human ortholog CYP2F1 in the lung has been implicated to be associated with tissue-specific toxicity induced by pulmonary toxicants, including NA, styrene, 3-methylindole, and benzene (Lanza et al.
One of the possibilities was the free-radical bromination of alkyl groups of readily available p-cresole and 3-methylindole. Our attempts to obtain 4-(tert-butyloxycarbonyloxy)benzyl bromide and N-Boc-(3-bromomethyl)indole from Boc-protected p-cresole and A-Boc-3-methylindole via radical bromination, using NBS/AIBN in refluxing C[Cl.sub.4] [17], was not successful.
Rumen metabolism takes up to three weeks to adjust to this rapid change in diet and is unable to cope, leading to the amino acid being converted to a compound called 3-methylindole, which has a toxic effect on the lungs, causing the symptoms of pneumonia.
In this work, some ILs were synthetized from 3-methylindole by changing hydrocarbyl groups, the synthetic method was shown (Fig.

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