4-aminopyridine


Also found in: Medical, Wikipedia.

4-aminopyridine

[¦fȯr ə‚mē·nō′pī·rə‚dēn]
(organic chemistry)
C5H6N2 White crystals with a melting point of 158.9°C; soluble in water; used as a repellent for birds. Abbreviated 4-AP.
Mentioned in ?
References in periodicals archive ?
In an animal experiment, the Kv channel could be blocked by 4-aminopyridine and cause contractions in the nonpregnant mouse myometrium.
Conversely, potassium-channel blockers such as 4-aminopyridine, or 4-AP, which are taken for relief of many MS symptoms, may improve heat-related fatigue or cognition problems.
channel inhibitors (glibenclamide + TEA + iberiotoxin + 4-aminopyridine + barium chloride).
These studies provided the rationale for the development of the potassium channel blocker, 4-aminopyridine, as the first Food and Drug Administration (FDA)-approved therapy for restoring function in MS [7].
The patent includes methods of improving lower extremity function and walking and increasing walking speed in multiple sclerosis patients, by administering less than 15mg of sustained release 4-aminopyridine (dalfampridine) twice a day.
Strychnine and 4-aminopyridine used as avicides are not only highly toxic to target birds but also pose secondary hazards to predatory and scavenger animals.
An animal experiment showed that neuromuscular block from a combination of neuromuscular blocking drugs and local anaesthetic is only partially reversed by neostigmine (18), but is effectively antagonised by 4-aminopyridine, a selective blocker of [K.
Results showed that astaxanthin exhibited a dose-dependent inhibition of 4-aminopyridine (4-AP)-evoked release of glutamate.
The 4-aminopyridine (4-AP) model of epilepsy allows for the induction of epileptiform activity while preserving excitatory and inhibitory synaptic activity.
received an Establishment Inspection Report (EIR) from the FDA stating that the company has passed pre-approval inspection (PAI) for the manufacture of 4-Aminopyridine, the active ingredient in Ampyra.
For 4-aminopyridine (4-AP) documentation of fatigue improvement is still scarce.
4-Aminopyridine acts as a weak base and a calcium mobilizing agent in triggering meiosis reinitiation and activation in the Japanese clam Ruditapes philippinarum.