fluorouracil

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fluorouracil:

see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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fluorouracil

[¦flu̇r·ō′yu̇r·ə‚sil]
(pharmacology)
C4H3FN2O2 Crystals that decompose at 282-283°C; used as an antineoplastic drug and as an inhibitor of deoxyribonucleic acid synthesis. Also known as 2,4-dioxo-5-fluoropyrimidine; 5-FU.
References in periodicals archive ?
Effects of combined intralesional 5-fluorouracil and topical silicone in prevention of keloids: A double blind randomized clinical trial study.
Keywords: Pterygium, Recurrent pterygium, 5-fluorouracil.
Conventional chemotherapy of cancer with 5-fluorouracil (5-FU) in combination with other agents improves the overall and disease-free survival of patients after surgery (Machover 1997).
The aims of this retrospective study included exploring the rational measures necessary to reduce the 5-Fluorouracil associated toxicity and related adverse reactions in cancer patients in order to ensure better quality of life for cancer patients and the measures which could ensure the cost effective chemotherapy.
Neoadjuvant treatment of unresectable liver disease with irinotecan and 5-fluorouracil plus folinic acid in colorectal cancer patients.
In an international, multicenter phase III study of 501 patients, induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (a combination known as TPF) was associated with a 30% reduction in mortality at 3 years, compared with standard induction chemotherapy with cisplatin and 5-fluorouracil (known as PF), Dr.
Data from the international trial also reveal that patients given FOLFOX 4 experienced less severe diarrhea, vomiting, and hair loss than those on standard IFL (irinotecan, 5-fluorouracil and leucovorin) treatment.
Dihydropyrimidine dehydrogenase (DPYD) is the initial and rate-limiting enzyme in the metabolism of the chemotherapeutic drug 5-fluorouracil (5-FU), thus affecting its pharmacokinetics, efficacy, and toxicity (1).
The Food and Drug Administration (FDA) today announced the approval of Eloxatin (oxaliplatin) injection for use in combination with infusional 5-fluorouracil (5-FU) and leucovorin for the treatment of patients with colorectal cancer whose disease has recurred or become worse following initial therapy with a combination of irinotecan with bolus 5-FU and leucovorin.
Neutropenic Enterocolitis in an Adult Patient With Colon Carcinoma After Receiving 5-Fluorouracil and Leucovorin.
Nasdaq:BGMR), Johnstown, Ohio, has received approval from Brazil's Agencia Nacional de Vigilancia Sanitaria (ANVS) to market 5-fluorouracil in Brazil.