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see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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References in periodicals archive ?
The cumulative probabilities of a requirement for corticosteroid at 5 and 10 years were 24.9% and 75.8% in the 5-ASA+AZA/ 6-MP group and 31.2% and 87.8% in the AZA/6-MP group, respectively.
AZA and 6-MP are inactive molecules that require bioactivation via a complex enzymatic metabolism.
Case 1.--A 38-year-old man with ulcerative colitis receiving 6-MP monotherapy underwent a liver biopsy for elevated aminotransferases.
The incidence of prematurity was about 70% higher among the women treated with azathioprine or 6-MP, compared with another control group of healthy women who were not treated with the drug.
Prior to the signing of the settlement agreement, Prometheus had filed a patent infringement lawsuit against Specialty alleging that the use or sale of Specialty's 6-MP Drug MonitR assay infringed certain of Prometheus' patent rights.
In the patients who had colectomies, 13 (54%) of 24 received 6-MP or azathioprine: 5 patients used the immunosuppressives a median of 9 months before cyclosporine, 3 patients used them during cyclosporine treatment, and 5 began them a median of 21 days after cyclosporine therapy.
A metaanalysis was performed in 2000 to evaluate treatment with 6-MP, compared with placebo, for inducing remission.
Azathioprine (Imuran[R]) and 6-MP are not considered therapeutic options in patients with mild disease.
Other medications include azathioprine and 6-mercaptopurine (6-MP), immunosupressive drugs which have been successful in reducing symptoms, closing fistulae, and reducing or eliminating the dependence on corticosteroids in some patients.
The maintenance therapy was given with 6-mercaptopurine (6-MP) 50 mg/[m.sup.2]/day, methotrexate (MTX) 15 mg/[m.sup.2]/day plus ATRA 45 mg/[m.sup.2] orally every other week for 24 months.
Treatment of chronic active Crohn disease with azathioprine (AZA) [9] or 6-mercaptopurine (6-MP) is effective in both inducing and maintaining remission in steroid-dependent and steroid-resistant patients (1-3).