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see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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References in periodicals archive ?
Allopurinol was first used to shift the metabolism of thiopurine compounds from 6-MMP to 6-TGN in poor responders to AZA or 6-MP (7).
Afterward, the patient remained on 6-MP therapy at the decreased dose of 50 mg/day, and aminotransferase levels normalized 1 month after the biopsy.
The incidence of prematurity was about 70% higher among the women treated with azathioprine or 6-MP, compared with another control group of healthy women who were not treated with the drug.
Probably safe drugs: 6-MP, azathioprine, ciprofloxacin, metronidazole, and cyclosporine.
In one patient series, IBD patients with impaired TPMT activity accounted for half of all cases of leukopenia and 27% of all cases of severe myelosuppression during 87 months of 6-MP or azathioprine therapy
Thiopurine methyltransferase (TPMT) inactivates 6-MP by methylation.
The methyl 6-MP (Me6-MP) formed was measured using a modification of the HPLC procedure described previously (14).