mercaptopurine

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mercaptopurine:

see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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References in periodicals archive ?
Edward, Multinuclear NMR spectroscopy and antiproliferative activity in vitro of platinum (II) and palladium (II) complexes with 6-mercaptopurine, J.
During this hospitalization, the 6-mercaptopurine and infliximab were discontinued, but the patient remained on low dose corticosteroids.
Grotegut and his associates at Duke most commonly use azathioprine and 6-mercaptopurine.
A 6-year-old male child with standard-risk group B-cell acute lymphoblastic leukemia (ALL) was being treated according to BFM-2002, in the maintenance phase of a chemotherapeutic regimen that included methotrexate and 6-mercaptopurine was admitted to our hospital complaining of small grouped maculopapular lesions on an erythematous base.
Children were defined as having IBD if they had either three or more health care visits for Crohn's disease or ulcerative colitis during the study's time frame, or "at least one health care contact for Crohn's disease or ulcerative colitis and at least one pharmacy claim for any of the following medications: mesalamine, olsalazine, balsalazide, sulfasalazine, 6-mercaptopurine, azathioprine, methotrexate, enteral budesonide, or biologies (infliximab, adalimumab, certolizumab, or natalizumab).
azathioprine, 6-mercaptopurine and antitumour necrosis factor.
The indication is for "reducing signs and symptoms and inducing and maintaining clinical remission in patients 6 years of age and older with moderately to severely active Crohn's disease who have had an inadequate response to corticosteroids or immunomodulators such as azathioprine, 6-mercaptopurine, or methotrexate.
A wide range of drugs has been implicated, including azathioprine, (2) infliximab, (2) Prednisolone, (3) immunosuppressive drugs, (4) cancer chemotherapy drugs, (5) alefacept, (2) etanercept, (2) 6-mercaptopurine, (6) and methotrexate.
During the second quarter the Food and Drug Administration approved Simponi (golimumab) for the treatment of moderately to severely active ulcerative colitis in adult patients who have demonstrated corticosteroid dependence or who have had an inadequate response to or failed to tolerate oral aminosalicylates, oral corticosteroids, azathioprine or 6-mercaptopurine.
In rheumatoid arthritis, methotrexate was the most effective companion agent, while in Crohn's disease, azathioprine and 6-mercaptopurine seemed to be effective in preventing AABs.
The patient was switched to another thiopurine drug, 6-mercaptopurine (6-MP), at 75 mg/day (1.
Janssen Biotech, a biotechnology company that was founded in Philadelphia, has received FDA approval for Simponi (golimumab) to treat moderately to severely active ulcerative colitis in adult patients with corticosteroid dependence or an inadequate response to or failure to tolerate oral aminosalicylates, oral corticosteroids, azathioprine, or 6-mercaptopurine, it was reported yesterday.