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see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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References in periodicals archive ?
Peiyun, A sensitive inhibition chemiluminescence method for the determination of 6-mercaptopurine in tablet and biological fluid using the reaction of luminol-Ag(III) complex in alkaline medium, J.
Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis.
After popular columnist Walter Winchell reported on the near-miraculous results, public demand for 6-mercaptopurine forced the Food and Drug Administration (FDA) to expedite its approval.
(4) With high-risk multisystem disease, as in the case reported, a chemotherapy regimen of vinblastine, prednisone, and 6-mercaptopurine for 12 months per LCH III protocol is indicated.
Sutherland, "Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease," Cochrane Database of Systematic Review, vol.
The "step-up" approach requires to start treatment with aminosalicylates (salazopirin or mesalazine) and, in case of therapeutic failure, corticotherapy followed by immunosuppressant treatment with azathioprine, cyclosporine, 6-mercaptopurine or methotrexate.
Treatment of gastrointestinal disorders in agammaglobulinemia with intravenous immunoglobulins alone may be ineffective in comparison to combination with immunomodulators such as azathioprine and 6-mercaptopurine, because most gastrointestinal manifestations of agammaglobulinemia appear to be due to defects in T-cell mediated immunity [1].
Moderate ulcerative colitis: (i) Mayo score between 6 and 10 (inclusive), (ii) endoscopic subscore of 2, (iii) failed 2 weeks of oral prednisone 40 Infliximab (Remicade[R]) mg-day (or IV equivalent for at least 1 week) and 3 months of azathioprine or 6- mercaptopurine, or where the use of immunosuppressants is contraindicated, (iv) stabilized with 2 weeks of oral prednisone [greater than or equal to] 40 mg-day (or IV equivalent for at least 1 week) but the prednisone dose cannot be tapered despite 3 months of azathioprine or 6-mercaptopurine, or where the use of immunosuppressants is contraindicated.
A previous study by Uchigata and Hirata [7] in 330 Japanese IAS patients demonstrated that 78% of the patients had spontaneous remission or resolution after avoiding culprit drug exposure, 9% required steroid treatment, 7.3% were treated with alpha-glucosidase inhibitor, 2.4% had severe hypoglycemia and required plasmapheresis, 1.8% underwent pancreatic surgery, and 0.6% were treated with other immunosuppressive drugs such as azathioprine and 6-mercaptopurine. Our patient was successfully treated with dietary management mainly by avoidance of simple carbohydrate.
The patient received 8 cycles of chemotherapy and is currently receiving maintenance chemotherapy with methotrexate and 6-mercaptopurine.
Azathioprine and 6-mercaptopurine can also cause side effects, including allergic reactions, leucopenia, pancreatitis, nausea, and abnormal liver function tests.