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These results suggest that AD in tree shrews is associated with up-regulation of numerous cellular processes in the hippocampus, including glycolysis, toxin response, carbohydrate processing, cellular projections, as well as with activity of 6-phosphofructokinase and M-band.
Yet, in a study of trained cyclists exercising at 2300 m, there was a reduction in the activity of 6-phosphofructokinase (PFK), a glycolytic rate-limiting enzyme (4).