Tissue staining with Congo red and immunohistochemistry were used to confirm AA amyloidosis and to exclude other forms of amyloidosis, particularly light chain amyloidosis.
EULAR also states that patients with FMF and AA amyloidosis should receive an intensified treatment with a maximal tolerable colchicine dose and biological treatment as required (9).
Amyloid load and clinical outcome in AA amyloidosis
in relation to circulating concentration of serum amyloid A protein.
The prognosis among those who require dialysis is not good, although some studies suggest increased survival among patients with AA amyloidosis
. In a retrospective study of 19 patients with AL amyloidosis and 20 with AA amyloidosis
, which required dialysis and were followed up after approximately 35 months, 15 (79 % ) with AL and 3 patients (15 %) with AA amyloidosis
Ozen et al., "Allelic variants in genes associated with hereditary periodic fever syndromes as susceptibility factors for reactive systemic AA amyloidosis
," Genes and Immunity, vol.
We strongly believe in KIACTA(TM)'s potential for the treatment of AA amyloidosis
, a truly devastating disease, and we look forward to putting our drug development expertise to the service of this product candidate," commented Dr.
No treatment protocol has been widely accepted for AA amyloidosis
, although colchicine, azathioprine, anti-TNF agents, and IL-1 and IL-6 antagonists are used increasingly with variable effectiveness.
Clinical and histological characteristics of renal AA amyloidosis
: a retrospective study of 68 cases with a special interest to amyloid-associated inflammatory response.
This observation has been made in AL and AA amyloidosis
. (46-50) In small series of patients with AL amyloidosis who underwent serial kidney biopsies, the extent of amyloid deposition seemed to be similar in biopsies that were performed before treatment and after treatment-induced resolution of proteinuria.
(23) In addition to the Congo red score, Hazenberg and colleagues (23) have also developed the quantitative assessment of amyloid in fat in AA amyloidosis
using an ELISA method.
(52,53) Although typically observed with chronic inflammatory states, such as rheumatoid arthritis or ankylosing spondylitis, more than 40 reported cases of AA amyloidosis
are associated with RCC and demonstrate systemic involvement.
Such extracts have been shown to accelerate amyloidogenesis in experimental animal models of AA amyloidosis
. Parenteral application of AEF together with an inflammatory stimulus, shortens the amyloid induction time from 3 to 4 weeks to 2 to 4 days.