Scharenberg studied the expression of the three best known efflux proteins associated with the ABCB1, ABCC1
, and ABCG2 genes in SP cells from hHSCs isolated from the bone marrow.
There was no difference between OR and ONR, except for the 2 genes ABCC1
(P = [5.51.sup.-05]) and KRT19 (P = 2.93 04) (see Table 13 in the online Data Supplement).
expression has been shown in many species, and in human, ABCC1
mRNA is expressed in various tissues including placenta, liver, and kidney [12,13].
Cole, "Expression and function of human MRP1 (ABCC1
) is dependent on amino acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2," Journal of Biological Chemistry, vol.
The full-length human ABCB1 cDNA in pBluescript KS (+) (Clone name: pMDRAl), human ABCC1
cDNA in pOTB7 (Clone name: RBbllBlO), and human ABCG2 cDNA in pOTB7 (Clone Name: IRAL039K21) were supplied by the Riken BRC DNA bank (Ibaraki, Japan).
Characterisation of the roles of ABCB1 ABCC1
ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo.
ABCB1 and ABCC1
expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment.
Of the 49 human ABC transporters, 15 are implicated in conferring resistance to chemotherapeutic agents in various cancers, and the most intensively characterized members are multidrug resistance 1 (MDR1 or P-glycoprotein, ABCB1), multidrug resistance protein 1 (MRP1, ABCC1
), and breast cancer resistance protein (BCRP, ABCG2) .
Within this concept, transporters from the OATP (SLC21) family such as OATp1A2, OATP1B3, OATP2B1, and OATP3A1 contribute to the cellular accumulation of E1S [11, 12], while ABC-efflux pumps from the MRP-family (ABCC1
and ABCC2), and the breast-cancer resistance protein (BCRP, ABCG2) mediates the efflux of E1S from the cells  ( Figure 2).
Release of S1P was abolished by none of the inhibitors of ATP Binding Cassette transporters (ABCA1, ABCB1, and ABCC1
) except ABCC1
For instance, ATP-binding cassette transporters encoded by genes known as ABCB1 and ABCC1
are involved in eliminating carcinogens from the lungs, protecting them against inhaled toxins.