ACE inhibitor


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Related to ACE inhibitor: Angiotensin receptor blocker, Beta blockers

ACE inhibitor

(ā'sē'ē`, ās) or

angiotensin-converting enzyme inhibitor

(ăn'jēōtĕn`sĭn), drug used to reduce elevated blood pressure (see hypertensionhypertension
or high blood pressure,
elevated blood pressure resulting from an increase in the amount of blood pumped by the heart or from increased resistance to the flow of blood through the small arterial blood vessels (arterioles).
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), to treat congestive heart failurecongestive heart failure,
inability of the heart to expel sufficient blood to keep pace with the metabolic demands of the body. In the healthy individual the heart can tolerate large increases of workload for a considerable length of time.
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, and to alleviate strain on hearts damaged as a result of a heart attack (see infarctioninfarction,
blockage of blood circulation to a localized area or organ of the body resulting in tissue death. Infarctions commonly occur in the spleen, kidney, lungs, brain, and heart.
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). ACE inhibitors block production of an enzyme that helps convert the protein angiotensin 1 into angiotensin 2, a protein that makes blood vessels constrict and promotes retention of fluid, raising blood pressure. Thus ACE inhibitors act to widen the blood vessels and make it easier for the heart to pump blood through the body. captopril (Capoten), ramipril (Altace), and enalapril (Vasotec) are commonly used ACE inhibitors. Angiotensin-receptor blockers (ARBs), such as losartan (Cozaar) and valsartan (Diovan), reduce hypertension by displacing angiotensin 2 from receptors on the surface of cells. ARBs are used as alternatives to the less expensive ACE inhibitors because they have fewer side effects.
References in periodicals archive ?
The finding is consistent with other suggestions in the literature that ACE inhibitors are better than diuretics at preventing heart disease, he added.
It is thought that the centrally active ACE inhibitors might protect from dementia and mental decline by decreasing oxidative stress and inflammation in the brain, she noted.
I would argue that since ARBs are similarly effective but much more expensive, not only are they no better than ACE inhibitors, they are actually worse.
The study that evaluated type 2 diabetes (194 patients) assessed patients with hypertension who used other antihypertensives to achieve normal blood pressure targets before ACE inhibitor initiation, a potential limitation.
Angioedema is a potentially life-threatening adverse effect of ACE inhibitors, with a reported incidence of 0.
ACE inhibitor should not be taken in double doses as severe hypotension may occur (Edmunds & Mayhew, 2014).
The other guideline recommendations are to not screen for CKD in asymptomatic adults without risk factors for it, to select an ACE inhibitor or ARB in patients with hypertension and stage 1-3 CKD, and to select a statin to manage elevated low-density lipoprotein cholesterol in patients with stage 1-3 CKD.
If you are taking an ACE inhibitor and are bothered by a cough, ask your doctor to evaluate whether the medication may be the cause.
So if your doctor prescribes an ACE inhibitor or calcium channel blocker, ask for a diuretic instead.
In the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) more than 33,000 patients with high blood pressure were randomly assigned to take either a diuretic (chlorthalidone) or one of two newer drugs, a calcium channel blocker (amlodipine) or an ACE inhibitor (lisinopril).
Although no adverse events were observed through the procedures, the results were significant for a higher variation of systolic BP and higher concentrations of bradykinin during and post-procedure for the ACE inhibitor group compared to control group (Perseghin et al.