acetylcholine receptor

(redirected from ACh receptor)
Also found in: Medical.

acetylcholine receptor

[ə‚sed·əl ′kō‚lēn ri‚sep·tər]
(cell and molecular biology)
A receptor in the membranes of certain cell structures, such as synapses or the neuromuscular junction, to which the transmitter substance acetylcholine binds. Nicotinic acetylcholine receptors are gated ion channels that open in response to acetylcholine, leading to an increase in membrane conductance; muscarinic acetylcholine receptors are G-protein-linked receptors inducing membrane ion channel changes or intracellular processes such as smooth muscle contraction.
References in periodicals archive ?
The brain M2 ACh receptor is known to contribute to impaired cognitive function, including a deficit in behavioral flexibility, working memory, and hippocampal plasticity [139, 140].
It is possible that the alteration of ACh receptor might have taken place in neuronal plexus which are nicotinic type.
Abnormal contracture knots may be initiated by a synaptic dysfunction at the motor endplate with the excessive acetylcholine (ACh) [7] release and changes in ACh receptor (AChR) [8] or acetylcholinesterase (AChE) [9] activities.
Afterward, DRC to Ach were performed in vessels pre-incubated for 30 min with Atropine (At, [10.sup.-5]M), an Ach receptor antagonist; and indomethacin (IND, [10.sup.-5] M), a cyclooxygenase (COX) inhibitor.
Other immunosuppressive drugs such as azathioprine (Imuran) or cyclosporine (Sandimmune) may decrease the immune stimulus for ACH receptor antibody production.
Since the lesioning procedure did not ensure a precise and complete removal of the efferent system, a genetically altered mouse ([euro]9 Ach receptor subunit knockout) was developed in which the peripheral cochlear Ach receptor sites were deleted.
Consolidating evidence for a role of nicotinic receptors also emerges from studies in which IT or speed of information processing measures have been assessed in patients with nicotinic Ach receptor (nAchRs) loss.
ACh travels across the synapse and binds with specialized ACh receptor sites (AChR) on the postsynaptic muscle cell membrane, called the motor end plate.
Afterwards, DRC to Ach were performed in vessels pre-incubated for 30 min with At, [10.sup.-5M,] an Ach receptor antagonist; and indomethacin IND, [10.sup.-5] M, a cyclooxygenase (COX) inhibitor.
Fishes also have been used to evaluate the effects of neurotoxins, such as the case of anatoxin-a, a nicotinic agonist produced by cyanobacteria that blocks cholinergic neurotransmission to compete for the ACh receptor. This toxin can cause death in humans and other animals.
AChE is responsible for the rapid cleavage of the neurotransmitter ACh in the synapse, thereby regenerating the ACh receptor and the excitability of the postsynaptical membrane.