acetylcholine receptor

(redirected from ACh receptor)
Also found in: Medical.

acetylcholine receptor

[ə‚sed·əl ′kō‚lēn ri‚sep·tər]
(cell and molecular biology)
A receptor in the membranes of certain cell structures, such as synapses or the neuromuscular junction, to which the transmitter substance acetylcholine binds. Nicotinic acetylcholine receptors are gated ion channels that open in response to acetylcholine, leading to an increase in membrane conductance; muscarinic acetylcholine receptors are G-protein-linked receptors inducing membrane ion channel changes or intracellular processes such as smooth muscle contraction.
References in periodicals archive ?
It is possible that the alteration of ACh receptor might have taken place in neuronal plexus which are nicotinic type.
Other immunosuppressive drugs such as azathioprine (Imuran) or cyclosporine (Sandimmune) may decrease the immune stimulus for ACH receptor antibody production.
Since the lesioning procedure did not ensure a precise and complete removal of the efferent system, a genetically altered mouse ([euro]9 Ach receptor subunit knockout) was developed in which the peripheral cochlear Ach receptor sites were deleted.
Consolidating evidence for a role of nicotinic receptors also emerges from studies in which IT or speed of information processing measures have been assessed in patients with nicotinic Ach receptor (nAchRs) loss.
ACh travels across the synapse and binds with specialized ACh receptor sites (AChR) on the postsynaptic muscle cell membrane, called the motor end plate.
AChE is responsible for the rapid cleavage of the neurotransmitter ACh in the synapse, thereby regenerating the ACh receptor and the excitability of the postsynaptical membrane.
may enter through an ACh receptor-complex in the LMBW similar to that of the mammalian nicotinic ACh receptor.