Recently, GWAS and multi-staged replication studies integrating quantitative trait loci expression performed in Japanese populations have identified a single-nucleotide polymorphism (SNP), rs340630, within the AF4/FMR2 family, member 1 (AFF1) associated with SLE at genome-wide significance level (11).
The genotype of AFF1 rs340630 polymorphism in the first study group was determined by Shanghai Biowing Applied Biotechnology Co.
Hardy-Weinberg equilibrium (HWE) of the AFF1 rs340630 polymorphism genotype distribution among the control group was assessed using the chi-square goodness of fit test.
The genotype and allele frequencies of the AFF1 rs340630 polymorphism among two study groups are shown in Table 1 and Table 2, respectively.
Association of AFF1 rs340630 polymorphism with the risk of RA in the first study group
Zhu et al., "AFF1
and AFF4 differentially regulate the osteogenic differentiation of human MSCs," Bone Res, vol.
Another vaccination-based approach consisted of administrating short fragments of [alpha]-synuclein conjugated to a carrier, also known as the AFFITOPE[R] AFF1
vaccine, which resulted in the stimulation of antibodies against the C-terminal part of [alpha]-synuclein in two mouse models of PD .
Items Aff3, Aff2, and Aff1
were related to the fourth dimension, Affection which explained a variance of 13.372 percent.
Target Full Name Context Pct Score ASH1L ashl (absent, small, or -0.59 > homeotic)-like (Drosophila) 0.99 RICTOR rapamycin-insensitive companion of -0.57 > mTOR 0.99 ITGB8 integrin, beta 8 -0.62 0.98 C20orf194 chromosome 20 open reading frame -0.72 0.97 194 SNF1LK SNF1-like kinase -0.39 0.97 FAM44B family with sequence similarity 44, -0.65 0.95 member B C10orf18 chromosome 10 open reading frame 18 -0.87 0.95 ZCCHC14 zinc finger, CCHC domain containing -0.5 0.94 14 AFF1
AF4/FMR2 family, member 1 -0.25 0.94 EML4 echinoderm microtubule associated -0.42 0.93 protein like 4 LCOR ligand dependent nuclear receptor -0.33 0.93 corepressor CCDC6 coiled-coil domain containing 6 -0.33 0.92 BNC2 basonuclin 2 -0.32 0.9 Apoptosis signaling is associated with miR-125b predicted targets.
Here we use Kac's indexing of affine Dynkin diagrams from [16, Table Fin, Aff1