Dysregulation of AKT
has been implicated in a variety of rare overgrowth diseases and cancers; however, there are currently no approved inhibitors of AKT
There are some occasion which causes to cancer formation such as over expression of Akt1 and its activation level (phosphorylated Akt
) and site is link to development and progression of colon cancer (Roy et al.
After LIPUS stimulation, phosphorylation levels of PI3K and AKT
were markedly increased relative to the control group (P<0.01 or P< 0.001, Figure 3A).
LncRNA NEAT1 impacts cell proliferation and apoptosis of colorectal cancer via regulation of Akt
Oral NaB group showed decreased genetic expression of AMPK (0.04 fold, p<0.001), mTOR (0.30 fold, p=0.04), Akt
(0.29 fold, p=0.67) and Sirt1 (0.83 fold, p=0.18).
We used the following antibodies: PI3K, p-Akt, Akt
, VEGF, and GAPDH (Cell Signaling Technology, MA).
They showed that AKT
comes in three distinct varieties residing in different kinds of brain cells and affecting brain health in very distinct ways.
Results showed that hypoxia-induced HSCs activation when AKT
phosphorylation was significantly enhanced (Figure 3(c)).
in  studied the mathematical model of PI3K/AKT signaling pathway in AKT
(Danvers, MA, USA) were as follows: GSK-3[beta] (BF0695), p-GSK-3[beta] (AF2016), Akt
(9272S), p-Akt (4060S), and [beta]-actin (8H10D10).
mTORC1 is composed of regulatory-associated protein of mTOR (RAPTOR), proline-rich AKT
substrate 40 kDa (PRAS40), mammalian lethal with Sec-13 protein 8 (mLST8) and DEP domain TOR-binding protein (DEPTOR), and it is inhibited by rapamycin, a macrolide produced by the bacterium Streptomyces hygroscopicus (Figure 1(a)).
Additionally, it has been reported that ARRBs can initiate a second wave of signal transmission independent of G proteins through signaling pathways mediated by molecules such as protein kinase B (AKT
) and ERK; in these pathways, ARRBs act as multifunctional adaptors [4-7].