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Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart.
Interactions of tenofovir and tenofovir disoproxil fumarate with drug efflux transporters ABCB1, ABCG2, and ABCC2; role in transport across the placenta.
4] Human genes: APOE, apolipoprotein E; SLCO1B1, solute carrier organic anion transporter family member 1B1; LPA, lipoprotein(a); SORTI, sortilin 1; ABCB1, ATP binding cassette subfamily B member 1; ABCG2, ATP binding cassette subfamily G member 2; HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase; CELSR2, cadherin EGF LAG sevenpass G-type receptor 2; PSRC1, proline and serine rich coiled-coil 1; KIF6, kinesin family member 6; CYP2C19, cytochrome P450 family 2 subfamily C member 19; P2RY12, purinergic receptor; CYP2C9, cytochrome P450 family 2 subfamily C member 9; CES1, carboxylesterase 1; UGT2B7, UDP glucuronosyltransferase family 2 member B7; VKORC1, vitamin K epoxide reductase complex subunit 1.
Data, mostly obtained by studies in rat intestine, suggest that MRP2 and ABCG2 transporters are mainly expressed in the duodenum and jejunum, and gradually decrease further down the intestinal tract [33, 34].
Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.
The present study helps to validate the results of a previous genomewide association study in which the single nucleotide polymorphism (SNP) rs2231142 in ABCG2 was associated with poor response to allopurinol (Clin Pharmacol Ther.
27] Apart from that, a various subfamily of ATP-binding cassette (ABC) is responsible for pumping out doxorubicin, including ABCB1, ABCB5, ABCB8, ABCC5, and ABCG2.
Hypoxia-inducible factor-2a is associated with ABCG2 expression, histology-grade and Ki67 expression in breast invasive ductal carcinoma," Diagnostic Pathology, vol.
The ATP-Binding Cassette Transporter Abcg2 is expressed in various healthy organs and protects, against toxic compounds and their metabolites as well as against hypoxia and oxidative stress, conditions present during ischemic heart injury.
Lack of associationbetween ABCB1, ABCG2, and ABCC2 genetic polymorphisms and multidrug resistance in partial epilepsy.
Han sido identificados dos transportadores ABC: la P-glicoproteina (MDR1) y la proteina de resistencia del cancer de mama ABCG2, los cuales son los que expulsan el colorante Hoechst 33342 de la subpoblacion SP, tanto de las celulas CMT como en las celulas normales (112).
The ABCG2 inhibitor, GF120918, was added at a final concentration of 50 [micro]g/mL, to confirm the gating area on flow cytometry.
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