Abortive Infection

abortive infection

[ə′bȯrd·iv in′fek·shən]
The viral infection of a cell in which viral components may be synthesized without the production of infective viruses. Also known as nonproductive infection.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Abortive Infection


in microbiology, contamination of a bacterial cell by a bacteriophage, after which neither reproduction of the phage particles and lysis (dissolution) of the bacterium nor lysogenesis occurs. Treatment of the contaminated cell with various substances, starvation of the bacteria in advance, the absence of calcium ions, and other influences can obstruct the reproduction of the phage in the cell. There are bacterial mutants in which contamination by a phage is confined to an abortive infection. The mechanisms of these processes vary.

In medicine the term “abortive infection” is used to designate the shortened course of an infectious disease that has few symptoms.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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Of the residual confirmed HBV-NAT yields, 8 (33.3%) were classified as window period, 1 (4.2%) as late acute window period or early recovery stage, 1 (4.2%) as anti-HBs breakthrough or abortive infection, and 14 (58.3%) as OBI.
In this study, HBcAb [sup]+ patients were also considered as affected by hepatitis B infection in this study.[sup][12] We excluded such kind of patients due to potential abortive infection or postinfection.
This repetitive cycle of abortive infection, cell death, inflammation and recruitment of additional CD4 T cells to the infection "hot zone" ultimately destroys the immune system and causes AIDS.
Thereafter, HEV RNA was detected only in the cells inoculated with the sample A homogenate (Figure 1); it was assumed that the signals from the other 3 samples represented residual inoculum or an abortive infection. The sample A culture showed a cycle threshold ([C.sub.t]) value of 27 on the day of inoculation (dpi 0) that increased to 35 on dpi 5, continued to increase until dpi 11, when it peaked at 38 and then began to decrease.
Complete DNA sequences have been achieved for four abortive infection mechanisms and two restriction modification systems isolated from lactococci.
Acute disease manifests itself as a lytic infection of rapidly dividing cells; chronic disease reflects a restricted or abortive infection of specific cell types (1).