ACE inhibitor

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ACE inhibitor

(ā'sē'ē`, ās) or

angiotensin-converting enzyme inhibitor

(ăn'jēōtĕn`sĭn), drug used to reduce elevated blood pressure (see hypertensionhypertension
or high blood pressure,
elevated blood pressure resulting from an increase in the amount of blood pumped by the heart or from increased resistance to the flow of blood through the small arterial blood vessels (arterioles).
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), to treat congestive heart failurecongestive heart failure,
inability of the heart to expel sufficient blood to keep pace with the metabolic demands of the body. In the healthy individual the heart can tolerate large increases of workload for a considerable length of time.
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, and to alleviate strain on hearts damaged as a result of a heart attack (see infarctioninfarction,
blockage of blood circulation to a localized area or organ of the body resulting in tissue death. Infarctions commonly occur in the spleen, kidney, lungs, brain, and heart.
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). ACE inhibitors block production of an enzyme that helps convert the protein angiotensin 1 into angiotensin 2, a protein that makes blood vessels constrict and promotes retention of fluid, raising blood pressure. Thus ACE inhibitors act to widen the blood vessels and make it easier for the heart to pump blood through the body. captopril (Capoten), ramipril (Altace), and enalapril (Vasotec) are commonly used ACE inhibitors. Angiotensin-receptor blockers (ARBs), such as losartan (Cozaar) and valsartan (Diovan), reduce hypertension by displacing angiotensin 2 from receptors on the surface of cells. ARBs are used as alternatives to the less expensive ACE inhibitors because they have fewer side effects.
References in periodicals archive ?
Inhibition of ACE with ACEI decreases the production of angiotensin II and thus lowers blood pressure.
A member of ACEI since 1996, Hardin served as the Chair of the Global Guidelines Task Force (2006-2009) and currently serves on the Global Guidelines Task Force (2003-present).
Hazel B McCanne-TSU ACEI (coadvisers, Laura Duhon and Dianne Pape) Eagles Educate ACEI (adviser, Tunde Szecsi).
To maintain the professional stature we need in the world today, it is critical that ACEI elects the most highly competent and committed Executive Board members.
I believe that ACEI can have a major, concrete impact upon the lives of hundreds of children with relatively little financial expenditure.
Mindi's goal at ACEI is to develop programs that will engage educators worldwide, promote professional growth, and positively impact education for children on a global scale.
Emerging Educators of Buffalo State College ACEI Student President: John McGowan Faculty Adviser: Dianne S.
We've tailored the e-mails to address the unique needs of particular groups and show how ACEI membership can meet those needs.
She respects the heritage and history of ACEI, and, at the same, she is aware of the challenges that ACEI faces in the future.
She became active with ACEI in Indiana and gradually expanded her service to include representing ACEI on the national and international levels.
The Elizabeth Breathwaite Student Leadership Award ($300) is presented to students who have shown evidence of leadership and participation in professional, social, school, and civic activities; interest in teaching or child-related occupations; and participation in ACEI activities.
As dedicated ACEI members living in today's fast-paced world, you are well aware of the need for sustainable leadership within our organization.