acetylcholine receptor


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acetylcholine receptor

[ə‚sed·əl ′kō‚lēn ri‚sep·tər]
(cell and molecular biology)
A receptor in the membranes of certain cell structures, such as synapses or the neuromuscular junction, to which the transmitter substance acetylcholine binds. Nicotinic acetylcholine receptors are gated ion channels that open in response to acetylcholine, leading to an increase in membrane conductance; muscarinic acetylcholine receptors are G-protein-linked receptors inducing membrane ion channel changes or intracellular processes such as smooth muscle contraction.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.
Muscarinic acetylcholine receptors (mAchRs) are G-protein coupled receptors located in neurons of the nervous system, cardiac and smooth muscles (2,3).
A patch clamp study of the nicotinic acetylcholine receptor of bovine adrenomedullary chromaffin cells in culture.
The regional distribution of VAChT situated at presynaptic cholinergic nerve terminals is similar to that of acetylcholine receptors situated at the postsynapses of cholinergic nerve terminals.
Nathanson, "The cysteine residue in the carboxyl-terminal domain of the [m.sub.2] muscarinic acetylcholine receptor is not required for receptor-mediated inhibition of adenylate cyclase," Journal of Neurochemistry, vol.
This increase in the NO synthesis has been involved with stimulation of M1 muscarinic acetylcholine receptors (23).
To our knowledge, this is the first comprehensive meta-analysis to examine the effects of [alpha]7-nicotinic acetylcholine receptor agonists on both cognitive deficits and negative symptoms in patients with schizophrenia.
In this study, we provide an assessment of the effects of a genistein diet upon jejunum motility and contractility, jejunum wall thickness, and a quantification of acetylcholine receptors (AChR) in ob/ob mouse jejunum.
Acetylcholine receptor (AChR) antibodies are most common and occur in 85% of patients [5]; however, small proportion of patients have other antibodies such as muscle specific kinase antibodies (anti-MuSK), antismooth muscle antibodies, and striational antibodies (antimuscle titin and anti-ryanodine receptor) [8].
Myasthenia Gravis (MG) is an autoimmune disease characterized by the decreased availability of acetylcholine receptors at the neuromuscular junction, resulting in fluctuating muscle weakness and fatigability.
Yoshikami et al., "Discovery, synthesis, and structure activity of a highly selective alpha7 nicotinic acetylcholine receptor antagonist," Biochemistry, vol.
Scopolamine (SCO) is a muscarinic acetylcholine receptor (mAChR) antagonist which disturbs learning and memory function in animals and humans similar to those conditions observed in the patients with AD [3].