Selective activation of the M1 muscarinic acetylcholine receptor
achieved by allosteric potentiation.
Muscarinic acetylcholine receptors
(mAchRs) are G-protein coupled receptors located in neurons of the nervous system, cardiac and smooth muscles (2,3).
A patch clamp study of the nicotinic acetylcholine receptor
of bovine adrenomedullary chromaffin cells in culture.
The regional distribution of VAChT situated at presynaptic cholinergic nerve terminals is similar to that of acetylcholine receptors
situated at the postsynapses of cholinergic nerve terminals.
Nathanson, "The cysteine residue in the carboxyl-terminal domain of the [m.sub.2] muscarinic acetylcholine receptor
is not required for receptor-mediated inhibition of adenylate cyclase," Journal of Neurochemistry, vol.
This increase in the NO synthesis has been involved with stimulation of M1 muscarinic acetylcholine receptors
To our knowledge, this is the first comprehensive meta-analysis to examine the effects of [alpha]7-nicotinic acetylcholine receptor
agonists on both cognitive deficits and negative symptoms in patients with schizophrenia.
In this study, we provide an assessment of the effects of a genistein diet upon jejunum motility and contractility, jejunum wall thickness, and a quantification of acetylcholine receptors
(AChR) in ob/ob mouse jejunum.
(AChR) antibodies are most common and occur in 85% of patients ; however, small proportion of patients have other antibodies such as muscle specific kinase antibodies (anti-MuSK), antismooth muscle antibodies, and striational antibodies (antimuscle titin and anti-ryanodine receptor) .
Myasthenia Gravis (MG) is an autoimmune disease characterized by the decreased availability of acetylcholine receptors
at the neuromuscular junction, resulting in fluctuating muscle weakness and fatigability.
Yoshikami et al., "Discovery, synthesis, and structure activity of a highly selective alpha7 nicotinic acetylcholine receptor
antagonist," Biochemistry, vol.
Scopolamine (SCO) is a muscarinic acetylcholine receptor
(mAChR) antagonist which disturbs learning and memory function in animals and humans similar to those conditions observed in the patients with AD .