acetylcholine receptor

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acetylcholine receptor

[ə‚sed·əl ′kō‚lēn ri‚sep·tər]
(cell and molecular biology)
A receptor in the membranes of certain cell structures, such as synapses or the neuromuscular junction, to which the transmitter substance acetylcholine binds. Nicotinic acetylcholine receptors are gated ion channels that open in response to acetylcholine, leading to an increase in membrane conductance; muscarinic acetylcholine receptors are G-protein-linked receptors inducing membrane ion channel changes or intracellular processes such as smooth muscle contraction.
References in periodicals archive ?
6] M atropine, a competitive muscarinic acetylcholine receptor antagonist; ii) [10.
Recently, Liu (2014) has shown the role of cholinergic neurotransmission, via the activation of the acetylcholine receptor alpha7, in the mediation of the conditioned incentive properties of external nicotine cues, for which reason manipulating the activity of the acetylcholine receptor alpha7 could be a target in the development of drugs to prevent relapse brought on by outward cues.
Moreover the insecticidal potency is influenced not only by the intrinsic actions on the targets but also by their accessibility to nicotinic acetylcholine receptors and metabolism in insects (Yamamoto et al.
Varenicline is a [alpha]4[beta]2 nicotinic acetylcholine receptor partial agonist which is used for the cessation of smoking (4).
Strong anatomic links also exist between muscarinic acetylcholine receptors and the brain dopaminergic system, especially muscarinic type-1 and type-4 (M1 and M4) receptors.
1976) Biochem ical studies on muscarinic acetylcholine receptors.
Chronic intraperitoneal endotoxin treatment in rats induces resistance to d-tubocurarine, but does not produce up-regulation of acetylcholine receptors.
Clinical correlations of antibodies that bind, block, or modulate human acetylcholine receptors in myasthenia gravis.
It is important to understand that the nondepolarizing blocking agents also competitively block acetylcholine receptors at the autonomic ganglia, producing cardiovascular side effects on heart rate and blood pressure.
This stimulant hits acetylcholine receptors in the nervous system, leading to improved alertness.

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