The relationship between antenatal and intrapartum risk factors for fetal acidaemia
was analysed using logistic regression model presented as odds ratio (OR) with 95% confidence intervals (CI).
Only 1.4% of infants with HIE 1 died, as opposed to 7.1% and 62.5% of those with HIE 2 and 3 respectively, defining asphyxia with inclusion of metabolic acidaemia
. There were no deaths among those who did not develop HIE.
These cases represent over 60% of all IMDs diagnosed in this period and the majority fall into 3 main categories, namely the organic acidaemias
(OAs), the urea cycle defects (UCDs) and the mitochondrial cytopathies.
Fetal heart rate patterns and ECG ST segment changes preceding metabolic acidaemia
Diagnosis of isovaleric acidaemia
by tandem mass spectrometry: false positive result due to pivaloylcarnitine in a newborn screening programme.
Neonatal death associated with isovaleric acidaemia
. Lancet 1967;2:439-42.
Intrapartum fetal surveillance aims to improve fetal outcomes by identifying fetuses with hypoxic acidaemia
and has the potential to promote fetal health and improve neonatal status at birth.
Jack Beattie, nine, from Catchgate, near Annfield Plain, County Durham, was diagnosed with methylmalonic acidaemia
when he was only 11 weeks old.
As the victim suffers from impaired liver function resulting in acidaemia
and hyperinsulinaemia hepatic gluconeogenesis and glycogenolysis occur.
She was two weeks old when she was diagnosed with propionic acidaemia
, a condition in which vital enzymes, produced mainly in the liver, are missing.
Sophie has a rare condition called Methyl Malonic Acidaemia
The management and outcome of propionic and methylmalonic acidaemia
. J Inherit Metab Dis.