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A condition of decreased alkali reserve of the blood and other body fluids.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a change in the acid-alkaline balance of the organism as a result of insufficient removal and oxidation of organic acids (for example, beta-hydroxybutyric acid). Usually these products are rapidly removed from the body. In febrile diseases, intestinal disorders, pregnancy, starvation, and such, they are retained in the body; this is manifested in mild cases by the appearance of acetoacetic acid and acetone in the urine (so-called ketonuria). In severe cases (for example, diabetes mellitus) it may lead to coma. Treatment consists of removal of the cause of acidosis (for example, by administering insulin in case of diabetes); there is also symptomatic treatment—soda and an abundance of fluids taken internally.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
This last step is very slow thus resulting in accumulation of formic acid in the body which leads to life threatening metabolic acidosis. Another postulated mechanism is the low hepatic levels of these enzymes in humans leading to methanol intoxication.
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The clinical signs presented in the current case, such as diarrhea, ruminal atony, and dehydration, were compatible with ruminal acidosis and rumenitis (AFONSO & MENDONCA, 2007; GONZALEZ et al., 2014).
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The researchers found that over a median follow-up of 5.7 years, there were 2,335 hospitalizations with acidosis. Time-dependent metformin use was not associated with incident acidosis overall (adjusted hazard ratio [aHR], 0.98; 95 percent confidence interval [CI], 0.89 to 1.08) or in those with eGFR 45 to 59 and 30 to 44 mL/min/1.73 m[sup.2] (aHR, 1.16 [95 percent CI, 0.95 to 1.41] and 1.09 [95 percent CI, 0.83 to 1.44]) compared with alternative diabetes management.
The patient was orotracheally intubated due to metabolic acidosis with high anion gap, which was treated using NaHC[O.sub.3].
A severe metabolic acidosis was detected on arterial blood gas for which he received intravenous sodium bicarbonate.