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A condition of decreased alkali reserve of the blood and other body fluids.



a change in the acid-alkaline balance of the organism as a result of insufficient removal and oxidation of organic acids (for example, beta-hydroxybutyric acid). Usually these products are rapidly removed from the body. In febrile diseases, intestinal disorders, pregnancy, starvation, and such, they are retained in the body; this is manifested in mild cases by the appearance of acetoacetic acid and acetone in the urine (so-called ketonuria). In severe cases (for example, diabetes mellitus) it may lead to coma. Treatment consists of removal of the cause of acidosis (for example, by administering insulin in case of diabetes); there is also symptomatic treatment—soda and an abundance of fluids taken internally.

References in periodicals archive ?
Hypokalemic periodic paralysis in Sjogren's syndrome secondary to distal renal tubular acidosis.
The term "renal tubular acidosis" (RTA) refers to a group of disorders in which hyperchloremic metabolic acidosis develop because of inability of the renal tubules to perform net renal acid excretion, despite the absence or out of proportion decrease in the glomerular filtration rate.
Eventually, an imbalanced state develops called metabolic acidosis, which is commonly associated with chronic kidney disease.
These three patients had metabolic acidosis with seizures.
Fortunately, this adverse impact on vitamin D metabolism caused by phosphate depletion during metabolic acidosis can be addressed very simply using potassium bicarbonate supplementation:
Hence we report this case to highlight the fact that patients presenting with hypokalaemic periodic paralysis with metabolic acidosis can be due to Renal Tubular Acidosis with primary Sjogren's syndrome.
As the acidosis was getting corrected, hypokalemia was evident, which was treated with initial intravenous infusion of 120 mmol over initial 12 h, followed by oral supplementation.
sup][3],[4] Improving the cardiac function and normalizing the circulatory system are crucial to overcome hypothermia and lactic acidosis in severe heart failure patients.
The interrelated combination of chronic metabolic acidosis, low exocrine pancreatic function, and intestinal dysbiosis can explain the widespread digestive disorders in the modern world.
Primary disorder: determine whether blood pH indicates acidosis (<7.
The concern is for development of lactic acidosis in patients because the renally excreted metformin may build up as a result of decreased renal function.