This last step is very slow thus resulting in accumulation of formic acid in the body which leads to life threatening metabolic acidosis
. Another postulated mechanism is the low hepatic levels of these enzymes in humans leading to methanol intoxication.
Prevalence of subacuteruminal acidosis
in Cattle and Buffaloes of district Okara and Lahore Punjab, Pakistan.
TRC101 represents a first-in-class drug candidate for the treatment of metabolic acidosis
, a chronic condition commonly caused by CKD that is believed to accelerate the progression of CKD, increase the risk of muscle wasting and cause the loss of bone density.
occurs in most patients who are treated with topiramate.
Cows that suffer sub-acute rumen acidosis
reduce production triggered by inconsistent feed intake, poor feed efficiency and reduced feed digestibility.
The clinical signs presented in the current case, such as diarrhea, ruminal atony, and dehydration, were compatible with ruminal acidosis
and rumenitis (AFONSO & MENDONCA, 2007; GONZALEZ et al., 2014).
Arterial blood gas measurement revealed severe metabolic acidosis
(pH 7.12, Pa[O.sub.2] (arterial partial pressure of oxygen) 85 mmHg, PaC[O.sub.2] (arterial partial pressure of carbon dioxide) 12.8 mmHg, base excess -24.6, bicarbonate 7.3 mmol/L, lactate 2.1 mmol/L, albumin 32 g/dL, anion gap (AG) 26 mmol/L and blood glucose 5.4 mmol/L on 0.4 Fi[O.sub.2] (fraction of inspired oxygen).
The researchers found that over a median follow-up of 5.7 years, there were 2,335 hospitalizations with acidosis
. Time-dependent metformin use was not associated with incident acidosis
overall (adjusted hazard ratio [aHR], 0.98; 95 percent confidence interval [CI], 0.89 to 1.08) or in those with eGFR 45 to 59 and 30 to 44 mL/min/1.73 m[sup.2] (aHR, 1.16 [95 percent CI, 0.95 to 1.41] and 1.09 [95 percent CI, 0.83 to 1.44]) compared with alternative diabetes management.
The patient was orotracheally intubated due to metabolic acidosis
with high anion gap, which was treated using NaHC[O.sub.3].
A severe metabolic acidosis
was detected on arterial blood gas for which he received intravenous sodium bicarbonate.