SXSM-enhanced TCA cycle due to increased aconitate hydratase
, succinyl-CoA ligase (GDP-forming) subunit alpha and beta (SUCLG1/2) and succinyl-CoA ligase (ADP-forming) subunit beta (SUCLGA2), isocitrate dehydrogenase2, and dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT, PDHB).
Enzyme System AAT Aspartate aminotransferase ACO Aconitate hydratase
ALD Fructose-bisphosphate aldolase AP-1 Glycil-leucine peptidase ARK Arginine kinase DIA Dihydrolipoamide dehydrogenase EST Esterase [beta]-GAL [beta]-galactosidase GAPDH Glyceraldehide-3-phosphate dehydrogenase GPI Glucose-6-phosphate isomerase G3PDH Glycerol-3-phosphate dehydrogenase NAD (+) IDH Isocitrate dehydrogenase NADP (+) LAP-1 Leucine aminopeptidase-1 LAP-2 Leucine aminopeptidase-2 MDH Malate dehydrogenase ME Malate dehydrogenase NADP (+) MPI Mannose-6-phosphate isomerase ODH D-octopine dehydrogenase PGD 6-phosphogluconate dehydrogenase PGM Phosphoglucomutase PP Phenyl-proline peptidase SOD Superoxide dismutase Abbr.
We analyzed seven different enzyme systems: aconitate hydratase
(Acn), diaphorase (Dia), isocitrate dehydrogenase (Idh), malate dehydrogenase (Mdh), phosphoglucoisomerase (Pgi), phosphoglucomutase, (Pgm) and Triose-phosphate isomerase (Tpi).