FDA information on medication errors involving Activase
constrains the photosynthetic potential of leaves at high temperature and CO2.
Moreover, proteins of chloroplasts were identified: ribulose-bisphosphate carboxylase activase
, heat-shock - related protein HSP 70, oxygen-evolving protein 1 as well as oxygen-evolving protein 2 and mitochondrial-ATP synthase, subunit d.
Artuso adds that the Activase
injection treats only the ischemic, not the hemorrhagic, stroke.
Of the 15 identified proteins of the metabolic pathways like PLA, FBA class I, GAPDH, RuBP-5-P, TPI, and CA were increased in 100 [micro]M As treatment except for TK and RuBisCO activase
. This finds support from Pandey et al.
and an uncharacterized protein with a molecular function annotation for ATP binding appeared in the same spot (spot 6; rubisco activase
was also detected in spot 3).
Now, USDA-ARS scientists are collaborating to crystallize rubisco activase
. Crystallization will allow researchers to study the activase
protein more closely, to visualize its structure and possibly manipulate its sequence so that it doesn't unravel at higher temperatures.
When it gets too hot, a rubisco helper protein called "rubisco activase
" shuts down, photosynthesis stops, and the plant stops growing.
Recently, the National Institute of Neurological Disorders and Stroke (NINDS) indefinitely put on hold its IMS III study, which examined whether a combined intravenous (IV) and intra-arterial (IA) approach to recanalization is superior to standard IV rt-PA (recombinant tissue plasminogen activator, a protein used to break down blood clots--in this case Activase
) alone when initiated within three hours of acute ischemic stroke onset.
"The FDA makes decisions largely based on American data, and we make guidelines based on all available data," he said, noting that safety data were also obtained from Genentech, maker of the rtPA activase
Salvucci ME, Osteryoung KW, Crafts-Brander SJ, Vierling E (2001) Exceptional sensitivity of rubisco activase
to thermal denaturation in vitro and in vivo.