FDA information on medication errors involving
Activase and TNKase.
Rubisco
activase constrains the photosynthetic potential of leaves at high temperature and CO2.
Moreover, proteins of chloroplasts were identified: ribulose-bisphosphate carboxylase
activase, heat-shock - related protein HSP 70, oxygen-evolving protein 1 as well as oxygen-evolving protein 2 and mitochondrial-ATP synthase, subunit d.
Artuso adds that the
Activase injection treats only the ischemic, not the hemorrhagic, stroke.
Of the 15 identified proteins of the metabolic pathways like PLA, FBA class I, GAPDH, RuBP-5-P, TPI, and CA were increased in 100 [micro]M As treatment except for TK and RuBisCO
activase. This finds support from Pandey et al.
Rubisco
activase and an uncharacterized protein with a molecular function annotation for ATP binding appeared in the same spot (spot 6; rubisco
activase was also detected in spot 3).
Now, USDA-ARS scientists are collaborating to crystallize rubisco
activase. Crystallization will allow researchers to study the
activase protein more closely, to visualize its structure and possibly manipulate its sequence so that it doesn't unravel at higher temperatures.
When it gets too hot, a rubisco helper protein called "rubisco
activase" shuts down, photosynthesis stops, and the plant stops growing.
Recently, the National Institute of Neurological Disorders and Stroke (NINDS) indefinitely put on hold its IMS III study, which examined whether a combined intravenous (IV) and intra-arterial (IA) approach to recanalization is superior to standard IV rt-PA (recombinant tissue plasminogen activator, a protein used to break down blood clots--in this case
Activase) alone when initiated within three hours of acute ischemic stroke onset.
"The FDA makes decisions largely based on American data, and we make guidelines based on all available data," he said, noting that safety data were also obtained from Genentech, maker of the rtPA
activase (Alteplase).
Salvucci ME, Osteryoung KW, Crafts-Brander SJ, Vierling E (2001) Exceptional sensitivity of rubisco
activase to thermal denaturation in vitro and in vivo.
