Keywords: Acute phase reactants
, Inflammation, Rheumatoid arthritis.
C-reactive protein is basically an acute phase reactant
, which has been to stay persistently elevated (6) in cases of acute appendicitis unlike the total count, which progressively decreases with time and C-reactive protein had a sensitivity of 87% and specificity of 50%.
Diagnostic difficulties in CAP cases generally necessitate the evaluation of multiple factors to differentiate viral and bacterial etiology, such as patient age, disease progression, accompanying symptoms, serum biomarkers, serum acute phase reactants
, radiological findings, presence of viral epidemics, and clinical response to antibiotics (5).
This may be an indication of fat cells playing a vital role in the production of acute phase reactants
like ferritin which may not be the gold standard for the evaluation of iron status in obese individuals.
Elevation of acute phase reactants
is useful for the diagnosis and for defining disease activity (6).
Acute Phase Reactants
as Novel Predictors of Cardiovascular Disease.
This latter group, the opsonophagocytic family of C-type lectins, functions predominantly as acute phase reactants
Our results suggest that measurement of both these sensitive acute phase reactants
enhances the utility of monitoring the acute phase response for clinical management and prognosis.
IL-6 being an acute phase reactant
and inflammatory mediator acts as a possible contributor for cardiac pathology.
Several recent research studies have suggested additional markers that may have prognostic value, including acute phase reactants
such as C-reactive protein.
Serum ferritin, the most specific indicator of iron deficiency, is an acute phase reactant
and its level is affected by inflammation.
In conclusion, a suggested arthritis screening profile consisting of the acute phase reactant
CRP, circulating cytokines (IFN-[gamma], IL-1[beta], IL-1Ra, TNF, GM-CSF, and VEGF), autoantibodies RF and anti-CCP and HLA-DRB1 high-resolution molecular typing shows promise to identify those patients who may benefit from a more aggressive treatment regimen or immediate biological biotherapy.