Hematopoietic recovery of acute radiation syndrome
by human superoxide dismutase-expressing umbilical cord mesenchymal stromal cells.
Blakely et al., "Medical management of the acute radiation syndrome
: recommendations of the Strategic National Stockpile Radiation Working Group," Annals of Internal Medicine, vol.
It is also being developed, with funding by the US Government, as a medical countermeasure against chemical and radiological weapons, where its initial target indications are as a protective agent against the effects of acute radiation syndrome
and delayed effects of acute radiation exposure.
The animal studies, conducted following guidance from the FDA relating to its animal rule pathway, are designed to evaluate PLX-R18 as a potential prophylactic countermeasure against acute radiation syndrome
(ARS) administered prior to radiation exposure.
Food and Drug Administration relating to its animal rule pathway, are designed to evaluate PLX-R18 as a potential prophylactic countermeasure against acute radiation syndrome
administered prior to radiation exposure.
According to the company, the lead investigational candidate EC-18 is in development for a variety of indications including Chemotherapy Induced Neutropenia (CIN), Chemoradiation Induced Oral Mucositis (CRIOM) and Acute Radiation Syndrome
(PSTI) announced that the Japan Patent Office has granted a patent for the treatment of acute radiation syndrome
(ARS) and its impact on the gastrointestinal tract.
Protectan CBLB502 is a "rationally designed recombinant derivative of the bacterial protein flagellin, which binds and activates the mammalian TLR5 cell surface receptor." (16) CBLB600 Series Protectans are "synthetic derivatives of mycoplasma lipopeptide, which promote activation of the antiapoptotic NF-kappaB pathway associated with acute radiation syndrome
." (17) Animal trials of Protectan have yielded promising results, and radical improvements in radiation exposure treatment are expected.
Acute radiation syndrome
. In:Conklin GG, Walker RI, eds.
About 50 people--most of them emergency workers--are known to have died of either acute radiation syndrome
or cancer as a direct consequence of the accident.
Local radiation injury results from direct contact with a radioactive source: In acute radiation syndrome
, the patient's entire body is exposed.