adamantane

(redirected from Adamantyl)

adamantane

[‚ad·ə′man‚tān]
(organic chemistry)
A C10H16 alicyclic hydrocarbon whose structure has the same arrangement of carbon atoms as does the basic unit of the diamond lattice.
References in periodicals archive ?
(20) Tetrahydrocannabinol, other than that which occurs in marijuana in its natural and unaltered state, including any compound, except nabilone or compounds listed under a different schedule, structurally derived from 6,6' dimethyl-benzo[c]chromene by substitution at the 3-position with either alkyl (C3 to C8), methyl cycloalkyl, or adamantyl groups, whether or not the compound is further modified in any of the following ways ....
the X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors," Bioorganic & Medicinal Chemistry Letters, vol.
Mitchell et al., "Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats," Clinical Science, vol.
Antibacterial activity of adamantyl substituted cyclohexane diamine derivatives against methicillin resistant Staphylococcus aureus and Mycobacterium tuberculosis.
Decomposition dose not simply progress in Block(61/39) and Block(36/64) because the thermal energy by heating was changed not only by decomposition of the adamantane unit but also the kinetic energy of polymer main chain, as the mobility of methacrylate main chain is derived more from the lower molecular weight of adamantyl methacrylate.
Santaniello, New Synthesis of 6[3-(1- adamantyl)-4-methoxyphenyl]-2-naphthoic acid and Evaluation of the Influence of Adamantyl Group on the DNA Binding of a Naphthoic Retinoid.
Surprisingly, introduction of the significantly larger adamantyl (12d) and triisopropylsilyl groups (12e) did not lead to loss of activity, while elimination of the three methyl groups from 1 diminished the potency 440-fold (12a).
Vicker et al., "Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11[beta]-hydroxysteroid dehydrogenase type 1," ChemMed-Chem, vol.
In this context, the small molecule AP736 (Figure 1) was recently synthesized from a 1,3-diphenylpropane skeleton through an optimization process involving the replacement of a phenyl group by dihydroxyl and adamantyl moieties [16]; importantly, AP736 was found to effectively suppress melanin production from melanocytes [17].
The purpose of the grafted end groups was to hinder the molecular interactions between PUs and the selected end groups, e.g., adamantyl, naphthyl, phenyl, and phenoxyphenyl groups, which commonly possess rigid ring structures that are incompatible with the flexible PUs.
In this regard, we are trying to obtain the experimental parameters of the fractal model to achieve the theoretical values of the permeability and solubility coefficients in amorphous polymers such as polynorbornene dicarboximides with different pendant groups (phenyl, adamantyl, and cyclohexyl), reported in previous work [24].
ALP activity was measured by the addition of 200 [micro]L of a chemiluminescent substrate, a phosphate ester of adamantyl dioxetane from the IMMULITE 2500 [TT.sub.3] assay (18, 19).