Antibacterial activity of adamantyl
substituted cyclohexane diamine derivatives against methicillin resistant Staphylococcus aureus and Mycobacterium tuberculosis.
Decomposition dose not simply progress in Block(61/39) and Block(36/64) because the thermal energy by heating was changed not only by decomposition of the adamantane unit but also the kinetic energy of polymer main chain, as the mobility of methacrylate main chain is derived more from the lower molecular weight of adamantyl
Santaniello, New Synthesis of 6[3-(1- adamantyl
)-4-methoxyphenyl]-2-naphthoic acid and Evaluation of the Influence of Adamantyl
Group on the DNA Binding of a Naphthoic Retinoid.
Surprisingly, introduction of the significantly larger adamantyl
(12d) and triisopropylsilyl groups (12e) did not lead to loss of activity, while elimination of the three methyl groups from 1 diminished the potency 440-fold (12a).
In fact, the adamantyl
group, when grafted to polymers, was shown to increase the glass transition temperature and the thermal stability of polymers [20, 21].
ALP activity was measured by the addition of 200 [micro]L of a chemiluminescent substrate, a phosphate ester of adamantyl
dioxetane from the IMMULITE 2500 [TT.
Therefore the incorporation of the adamantyl
moiety is capable to induce relatively high lipophilicity which can improve the biological availability of some molecules.
Sustained light emission is detected after injection of a phosphate ester of adamantyl
dioxetane (chemiluminescent substrate) and is proportional to serum LBP concentrations.
The chemiluminescent substrate used for the enzymatic reaction is an ester of adamantyl
Finally, the chemiluminescent substrate, a phosphate ester of adamantyl
dioxetane, is added.
Chemiluminescence enzyme immunoassay of alpha-fetoprotein based on an adamantyl
dioxetane phenyl phosphate substrate.
Further studies on the application of chemiluminescent reactions and stabilized adamantyl
dioxetane substrates for alkaline phosphatase labels in immunoassay and DNA analysis were undertaken in collaboration with Dr.