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(named after the English physician T. Addison, who first described it in 1855), also known as bronzed skin disease. It is caused by a chronic malfunction of the suprarenal cortex of the adrenal glands and is externally characterized by a bronze coloration of the skin. A relatively rare disease, it manifests itself primarily in the 15–to 30–year age group. Addison’s disease is caused by the destruction of the adrenal glands, usually by tuberculosis or more rarely by syphilis, atrophy of the suprarenal cortex, tumor, or amyloidosis. The disease develops gradually.
As a result of the decreased secretion of adrenocortical hormones (mineralcorticoids), the secretion of sodium and chlorides in the urine increases while their amount in the blood decreases, which, together with retention of potassium, leads to the dehydration of the organism. The blood pressure falls. The lowered glucocorticoid content disrupts carbohydrate and protein exchange, causing muscular weakness, adynamia, rapid fatigue, and weight loss. The dark bronze coloring is caused by a special pigment. Hormone treatment is indicated.
REFERENCESZefirova, G. S. Addisonova bolezn’. Moscow, 1963. (With bibliography.)
“Bolezni endokrinnoi sistemy.” Edited by V. G. Baranov. (Rukovodstvo po vnutrennim bolezniam, vol. 7.) Leningrad, 1966.