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Nectin-1 is an immunoglobulin-like adhesion molecule that is widely expressed in epithelial tissues and it participates in forming the adherens junctions, which serve to connect cells within the skin.
This study examined the relationship between inflammatory cytokines (interleukin [IL]-6, tumor necrosis factor [TNF]-a, and IL-10) and adherens junctions (E-cadherin, p120-catenin), which were ameliorated by glutamine in VILI, both in vitro and in vivo.
proteins that comprise tight junctions, adherens junctions and gap
The previous concept of BBB is a pure endothelial barrier of the brain, a physical barrier comprised of tight junctions (TJs) and adherens junctions (AJs) that limit paracellular diffusion of solutes between the blood and the brain [2, 3].
The endothelial cell-cell junctional complex that controls paracellular permeability is composed of adherens junctions, tight junctions, and desmosomes.
Higher expression of CDH5 at multiple time points indicates adherens junctions may result in decreased permeability in the biopaper model.
Our observations in monolayer culture of keratinocytes also fit this picture, with a clear membrane localization of C4.4A at cell-cell interaction points, suggesting a role of C4.4A in, for example, adherens junctions. In addition, the carbohydrate-binding lectin galectin-3, which has been implicated in cell-cell interactions and cell adhesion, has been identified as a ligand for C4.4A [48].
Bioinformatics predicted that, by targeting several genes, these six miRNAs significantly (p < 0.001) regulated interrelated pathways associated with the cytoskeleton, inflammation, and metabolism, that is, FoxO, cell cycle, toll-like receptor, MAPK, AMPK, p53, PI3K-Akt, adipocytokine, tight and adherens junctions, focal adhesion, mTOR, PPAR, TGFbeta, and apoptosis (Table 3 and Figure 2).
VE-cadherin is an adhesion molecule that contributes to adherens junctions formation between endothelial cells.
It has been shown that ZO-1, as well as indeed other submembrane proteins (ZO-2, ZO-3, etc.), interacts directly with occludin and claudins and associates with the adherens junctions as well as gap junctions [2].
c-Src also independently regulates focal adhesions and adherens junctions, both of which are key in regulating cell adhesion (16, 17).