There are today 252 companies plus partners developing 308 targeting adherens junctions
drugs in 1120 developmental projects in cancer.
These protective cells (human newborn foreskin shown) can exist as sheets of tissue that are held tightly together by several structures including adherens junctions
(green, blue shows cell nuclei).
Nachyline stimulates the formation of adherens junctions
, boosts keratinocytes differentiation, reinforces the cohesion and stratification of epidermis and contributes to the organization of the stratum comeum, according to Silk.
GI mucosal barrier integrity is maintained by junctional complexes between epithelial cells including tight junctions, desmosomes and adherens junctions
Among the topics are cadherins, adherens junctions
and desmosomes, integrins and focal contacts, receptor tyrosine phosphatases, Notch and Slit-Robo signaling, adhesive binding to collagen and fibrillin, and complex adhesive mechanisms involved in leukocyte migration and malaria.
Adjudinmediated junction restructuring in the seminiferous epithelium leads to displacement of soruble guanylate cyclase from adherens junctions
," Journal of Cellular Physiology 208(1): 175-187.
Much of this is performed via three mechanisms existing between the intestinal microvilli: tight junctions, adherens junctions
Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions
One domain consists of the contacts between the sarcolemma and the junctional sarcoplasmic reticulum (cytoskeletal domain), another contains caveolae (caveolae are microdomains of the plasma membrane that have been implicated in signal transduction), and the third contains adherens junctions
, which are also referred to as membrane-associated dense bodies.
Disruption of Sertoli-germ cell adhesion function in the seminiferous epithelium of the rat testis can be limited to adherens junctions
without affecting the blood-testis barrier integrity: An in vivo study using an androgen suppression model," Journal of Cellular Physiology 205(1): 141-157.