cell adhesion molecule

(redirected from Adhesion molecules)
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cell adhesion molecule

[¦sel ad‚hē·zhən ′mäl·ə·kyül]
(cell and molecular biology)
A class of membrane proteins comprising the outer surfaces of cell membranes in the developing nervous system that is thought to be intimately involved in guiding development during embryonic life. Abbreviated CAM.
References in periodicals archive ?
Specifically, the role of soluble adhesion molecules in the pathogenesis of idiopathic sudden SNHL was investigated in two prospective studies.
Adhesion molecules (ICAM-1 and VCAM-1) and diabetic retinopathy in type 2 diabetes.
Objective: To observe the changes and correlations of serum interleukins (ILs), adhesion molecules and soluble E-selectin (sE-selectin) in children with allergic rhinitis, asthma and both diseases.
Though EpCAM belongs to a big family of adhesion proteins, it is structurally similar to none of four families of adhesion molecules: cadherins, integrins, selectins and a superfamily of immunoglobulins.
Integrins are adhesion molecules comprised of heterodimers for alpha and beta subunits.
These adhesion molecules play a crucial role in the immune system response by promoting cell-cell and cell-stroma interactions and leukocyte migration [53].
MIF might also contribute to cell recruitment by induction of MCP-1 [9] and other inflammatory mediators, such as adhesion molecules [10].
The immunoglobulin superfamily (IgSF) is the largest and most well documented cell adhesion molecule subgroup, although not all genes in this family are cell adhesion molecules.
The discovery of the carcinoembryonic antigen (CEA) as a tumor marker for colorectal carcinoma in 1965 by Gold and Freedman [1] was the milestone for identifying a much wider family of 12 carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) which mediate intricate mechanisms of modulation and dysregulation during complex biological processes regarding cancer progression, inflammation, metastasis, and angiogenesis [2].
Vascular endothelium in terms of deranged metabolic milieu of T2DM loses antiinflammatory, antiadhesive, antiplatelet abilities, expreme leukocyte and platelet adhesion molecules, promotes smooth muscle cell proliferation and migration.
It exhibits anti-inflammatory properties by preventing the migration of leukocytes and the expression and induction of adhesion molecules.