As a conclusion, the relationship between adiponectin
and breast cancer is likely to be based on many different mechanisms.
Consequently, there are several important factors that related with endoscopic gastritis like BMI, Helicobacter pylori, lipid profile and adiponectin
. This study assesses the effect of these factors and association of adiponectin
with these factors.
Emerging evidence suggests that adiponectin
enhances glucose uptake by increasing GLUT4 translocation to the cell membrane  and promotes fatty acid oxidation by activating adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), p38-mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha pathways [9,10].
A study published in JAMA, (5) involving meta-analysis of 13 prospective studies with a total of more than 14,500 participants and 2,623 cases of type 2 diabetes, demonstrated a correlation between increasing adiponectin
levels and a declining risk of the disease, across diverse populations.
In this regard, some molecules so-called adipokine (Mitchell et al., 2005), including leptin (Ebihara et al., 2001; Wolf et al., 2002) and adiponectin
(Maeda et al., 2002; Yamauchi et al., 2003), which are secreted by the adipocytes, may modulate the sensitivity of insulin, the action of which activates multiple signaling events after phosphorylation of insulin receptor and several other molecules in type-2 diabetes (Senthil et al., 2001; Sakaue et al., 2003).
Leptin and adiponectin
, hormones released primarily from fat cells, are known to play roles in appetite regulation, insulin resistance, lipid metabolism, blood pressure and the development of metabolic syndrome.
It appears that adiponectin
plays an important role in the TZD-elicited insulin sensitization .
The pleiotropic protective effects of the adiponectin
occurs via several postulated mechanisms that could, potentially, reduce the risk of T2DM and its associated complications.
To our knowledge, no prior meta-analysis has examined the prognostic role of adiponectin
level in patients with heart failure.
, a large adipokine secreted from adipose tissue, attracts attention with its anti-inflammatory, anti-atherogenic, anti-angiogenic, and insulinsensitizing properties, as well as its beneficial role in glucose metabolism [6, 7].
, which is an adipocytokine, has anti-inflammatory properties; and it sensitizes the body to insulin.