androgen

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androgen

(ăn`drəjən): see testosteronetestosterone
, principal androgen, or male sex hormone. One of the group of compounds known as anabolic steroids, testosterone is secreted by the testes (see testis) but is also synthesized in small quantities in the ovaries, cortices of the adrenal glands, and placenta, usually
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Androgen

One of a class of steroid hormones. Androgens play a major role in the development and maintenance of masculine secondary sexual characters, for example, the seminal vesicle and prostate gland of the male mammal, and the comb, wattles, and spur of the male fowl. They also influence certain other secondary sexual characters, such as hair growth pattern and voice quality in humans. In the fowl, they affect the pattern and seasonal coloration of its feathers, as well as crowing. In addition, androgens affect nitrogen metabolism (anabolic). Androgens are produced in the testis, ovary, adrenal, and most likely, in the placenta. A small portion of the androgen is from corticoids, or adrenal cortex steroids, and from other C21 steroids, such as progesterone. See Hormone, Ovary, Progesterone, Steroid, Testis

McGraw-Hill Concise Encyclopedia of Bioscience. © 2002 by The McGraw-Hill Companies, Inc.

androgen

[′an·drə·jən]
(biochemistry)
A class of steroid hormones produced in the testis and adrenal cortex which act to regulate masculine secondary sexual characteristics.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
McKenna, "Dissociation of adrenal androgen and cortisol secretion in Cushing's syndrome," Clinical Endocrinology, vol.
The clinical symptoms of CAH directly result from either the deficiencies in mineralocorticoid or glucocorticoid production or from the overproduction of adrenal androgens. Mineralocorticoid deficiency leads to renal salt wasting, which results in severe dehydration ifleft untreated.
Although delayed pubic hair development has been observed previously, no data on adrenal androgens have been reported in patients with IGSF1 deficiency.
DHEA is used as a marker of adrenal androgen production; abnormally low concentrations of DHEA may occur in patients with adrenal insufficiency, older adults, and peri- and postmenopausal women.
Adrenal androgens, DHEAS, DHEA, and androstenedione, contribute to 95% of the estrogenic activity in women and are responsible for more than 50% of the androgenic activity in women.
Regardless of the patient's BMI, those who present with symptoms of PCOS, including oligo- or amenorrhea, infertility, acne, hirsutism, or ovarian cysts, should receive a thorough workup including evaluation of ovarian and adrenal androgen hormones in addition to an assessment of insulin utility.
Some studies suggest that insulin is a negative modulator of adrenal androgen metabolism [37, 38], although some studies using insulin sensitizers in PCOS women showed a decrease of adrenal androgens after their administration [9, 39]; however this event could be consequent to decreases in LH levels that also occurs after metformin administration to these women [39].
This in turn stimulates estrogen production in the adrenal cortex or adrenal androgen conversion to estrogen in peripheral tissue.
Dr Notelovitz pointed out that androgens may improve symptom relief in three ways: (1) by lowering sex hormone-binding globulin (SHBG) levels, which, in turn, results in a greater amount of bioavailable estrogen; (2) by a direct effect of androgens; or (3) by increased bioavailability of adrenal androgens (low adrenal androgen bioavailability may be induced by estrogen-alone therapy).
Prevalence of 3[beta]-hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia in hyperandrogenic women with adrenal androgen excess.
As an adrenal androgen, DHEA acts as a steroid precursor for gonadal and peripheral testosterone and estrogen production.
These deficits trigger a compensatory increase in production of testosterone and adrenal androgens. Correction of these aforementioned deficiencies usually reduces and normalizes the androgen excesses and associated hirsutism, although slowly.