Amyloidosis

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amyloidosis

[‚am·ə·loi′dō·səs]
(medicine)
Deposition of amyloid in one or more organs of the body.

Amyloidosis

 

or amyloid dystrophy, a disorder of protein metabolism accompanied by the formation within tissues of a specific protein polysaccharide complex known as amyloid. The progress of the disease is associated with distortion of the protein-synthesizing function of the reticuloendothelial system and with accumulation of anomalous proteins in the blood plasma which act as autoantigens and also stimulate the formation of autoantibodies. As a result of antigen-antibody interaction, there is deposition of widely dispersed proteins which figure in the formation of amyloid. Once deposited in tissues, such as vascular and gland walls, the amyloid displaces functionally specialized elements of the organ; this process leads to the destruction of the organ.

Several types of amyloidosis are recognized: primary, secondary, and senile amyloidosis; amyloidosis with multiple myeloma; and localized tumorlike amyloidosis. Primary amyloidosis has no connection with any other disease; it affects mainly the cardiovascular system, alimentary tract, muscles, and skin. Secondary amyloidosis develops subsequent to other diseases which are accompanied by prolonged suppuration and tissue breakdown, such as tuberculosis, syphilis, and rheumatoid arthritis. It most often affects the spleen, liver, kidneys, adrenal glands, and intestines. Senile amyloidosis usually involves the heart. Amyloidosis may be either general or localized. Im-munodepressive and hepatic preparations are used in its treatment.

V. V. SEROV

References in periodicals archive ?
Although AD occurs both in children and adults, the studies in childhood AD are much more than that in adult AD. In China, there has been no large-scale study on adult/adolescent AD.
Bruce VanWyngarden, editor of the Memphis Flyer, says a decade ago his paper "was pretty much open to whatever." But in the mid-'90s, the 53,000-circulation weekly began refusing ads from "houses of ill-repute" and censoring photos in adult ads. VanWyngarden says the paper will still take ads from a topless bar--as long as there aren't actual topless women in the ads.
In most countries, the peak prevalence of adult AD occurred in the 35- to 44-year-old age group, then fell steadily.
Do the Danish results apply to less-severe cases of adult AD? Are those patients also at increased risk of MI?
As in childhood, the sites of involvement in adult AD can be anywhere on the body, but the most common areas of involvement in adults are the flexural areas of the arms and legs, the nape of the neck, and the hands.
To characterize early pediatric AD skin phenotype, they assessed lesional and nonlesional biopsies from 19 children under age 5 years (mean, 1.3 years) within 6 months of moderate to severe disease onset, as well as those from age-matched controls and adults, and found that, compared with adult AD, early AD involves comparable or greater epidermal hyperplasia and cellular infiltration, similar strong activation of Th2 and Th22 axes, and some Th1 skewing.
The Danish study is the latest in a very recent flurry of research pointing for the first time to increased cardiovascular risk in adult AD. Earlier this year, investigators at Northwestern University, Chicago, reported finding that adult AD patients have increased levels of cardiovascular risk factors (J Allergy Clin Immunol.
They found that ads targeted at children emphasized food packaging and street views of the restaurants, whereas adult ads emphasized the images of the food sold there.
In September 2010, after several murders were linked to adult ads on Craigslist, the site announced it would ban sex-related advertising in the United States (in truth, the ads are still there, just well hidden).
Backpage.com adult ads draw AG ire, San Antonio Express-News
There are no adult ads in this week's edition of the Orlando (Fla.) Weekly -- just a blank page where they would be -- and there might not be any in the alternative paper next week, either.
Similarly, interpersonal interaction--couples engaged in sexual behavior--is significantly more evident in young adult ads. Reader age is the only variable to predict the incidence of sexual behavior in ads, as young readers are twice as likely to see erotic interaction in ads than are mature adults.