Caption: Figure 2: Thickening of afferent arterioles and arcuate arteries in hyperuricemic rats.
(c and d) Correlation between urinary 8OHdG levels and the degree of podocytopathy, as determined by desmin-positive area (c), or the degree of arteriolopathy, as determined by the afferent arteriole thickness (d).
In addition, the decreased volume detected by the stretch receptors in the afferent arteriole leads to the release of renin into the systemic circulation resulting in the extrarenal production of AII.
The ARM, particularly the myogenic component, attempts to compensate by dilating the afferent arteriole, but this becomes dysfunctional when the MAP falls below about 70-80 mmHg.
The walls of afferent arterioles
were effaced by smudgy eosinophilic material that severely narrowed the vessel lumens, and nuclear pyknosis and karyorrhexis were seen within the altered arteriolar walls (Figure 1).
G: glomeruli; AF: afferent arteriole
; EF: efferent arteriole; RA: cruciate radial artery; RV: cruciate radial vein; AA: arcuate artery; AV: arcuate vein; and VR: vasa recta.
Cyclosporine A used in its treatment induces ischemia and the damage of the epithelial cells of renal tubules by the vasoconstriction of afferent arterioles
. In experimental tests and the culture of human tubular cells in vitro it has been demonstrated that ischemic injury increases the NGAL mRNA [8,22].