African sleeping sickness


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African sleeping sickness

[′af·ri·kən ′slēp·iŋ ′sik·nəs]
(medicine)
A disease of humans confined to tropical Africa, caused by the protozoans Trypanosoma gambiense or T. rhodesiense; symptoms include local reaction at the site of the bite, fever, enlargement of adjacent lymph nodes, skin rash, edema, and during the late phase, somnolence and emaciation. Also known as African trypanosomiasis; maladie du sommeil; sleeping sickness.
References in periodicals archive ?
A headline diagnosis of an inoculation chancre of East African sleeping sickness was considered, which was confirmed by a thick smear and QBC, revealing trypanosomes (Fig.
Because pafuramidine is more user-friendly than existing therapies, we anticipate that it would be available in community clinics as well as at current African sleeping sickness treatment centers.
In December 2007, Anacor established a partnership with the Drugs for Neglected Diseases initiative, or DNDi, to develop new therapeutics for African sleeping sickness, visceral leishmaniasis and Chagas disease.
More than 60 million people are exposed to African sleeping sickness in Sub-Saharan Africa.
African sleeping sickness, caused by Trypanosoma brucei, gradually brings on devastating neurological symptoms that affect the sleep cycle.
In their quest to find a weakness in the single-celled parasite that causes African sleeping sickness, researchers have identified an enzyme that appears indispensable to the microbe's survival.
African sleeping sickness in tourists returning from Tanzania: the first 2 Italian cases from a small outbreak among European travelers.
And the agency's reaction to those applications will give antisense companies their best clue yet about the regulatory hurdles they can expect as they seek approval for oligos aimed at a variety of diseases, including influenza, cervical cancer and African sleeping sickness.
Piet Borst and his colleagues at the Netherlands Cancer Institute in Amsterdam report similar success in using the neomycin gene to replace a targeted gene in Trypanosoma brucei, which causes African sleeping sickness.
The two first-place winners will use the 10GB sequencing award to study African sleeping sickness drug resistance and ant fungal garden metagenomes.
1 NATURE, Vladimir Volloch and his colleagues at the Boston Biomedical Research Institute describe their work with the protozoan Trypanosoma brucei, which causes African sleeping sickness.
French researcher Claude Helene, of the National Institute for Health and Medical Research in Paris, has used antisense DNA to interrupt the life cycle of the protozoan Trypanosoma brucei, which causes African sleeping sickness.

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