macular degeneration

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Related to Age-related macular degeneration: glaucoma, diabetic retinopathy

macular degeneration,

eye disorder causing loss of central vision. The affected area, the macula, lies at the back of the retina and is the part that produces the sharpest vision. The most serious visual impairment occurs when abnormal blood vessels form and leak serous fluid or bleed into the tissue of the macula, ultimately producing scar tissue. Peripheral (side) vision is unaffected. Onset may be acute with hemorrhage but usually is gradually progressive. Although some vision is retained, the ability to read, recognize faces, and drive a motor vehicle is greatly reduced. The condition is painless.

Macular degeneration is a major cause of vision impairment among elderly people. Although its underlying cause is unknown, it sometimes appears to run in families. Serious macular degeneraton, if diagnosed early, may have its progress stemmed by laser or photodynamic (cold laser and drug) treatment that closes leaking vessels. Antiangiogenic drugs, which inhibit the formation of new blood vessels, can be injected into the eye to stop degeneration and in some cases even improve vision. Sudden change in vision in someone over age 50 thus requires immediate medical attention.


See H. Grunwald, Twilight: Losing Sight, Gaining Insight (1999).

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References in periodicals archive ?
Shah, "Diagnosis of age-related macular degeneration," in Age-Related Macular Degeneration: Diagnosis and Treatment, A.
Johnson et al., "A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration," Proceedings of the National Academy of Sciences of the United States of America, vol.
Chan, "Aging is not a disease: distinguishing age-related macular degeneration from aging," Progress in Retinal and Eye Research, vol.
(17.) Seddon JM, Willett WC Speizer FE, Hankinson SE, A prospective study of cigarette smoking and age-related macular degeneration in women.
Another study report, "Dietary Intake of Antioxidants and Risk of Age-Related Macular Degeneration," was published in the Journal of the American Medical Association (December 28, 2005).
Regionally, the Americas age-related macular degeneration market is segmented into two major regions, namely, North America and South America.
According to the company, it holds the worldwide exclusive rights for LBS-008, a first-in-class oral therapy that prevents the buildup of toxins (A2E) in the eye that cause Stargardt disease and contribute to atrophic Age-related Macular Degeneration (dry AMD).
OpRegen is being evaluated in a Phase 1/2a clinical trial for the treatment of dry age-related macular degeneration.
[USA], Oct 22 ( ANI ): According to a new study eating vegetable nitrates, found mainly in green leafy vegetables and beetroot, could help reduce your risk of developing early-stage age-related macular degeneration (AMD), an eye disease that causes vision loss.
What You Must Know About Age-Related Macular Degeneration Jeffrey Anshel, OD & Laura Stevens, M.Sci Square One Publishers 115 Herricks Road, Garden City Park, NY 11040 9780757004490, $17.95, PB, 288pp,
What You must Know About Age-Related Macular Degeneration: How You Can Prevent, Stop, or Reverse AMD tackles a difficult problem: an age-related eye condition that is a big cause of vision loss in people over fifty.
What You Must Know About Age-Related Macular Degeneration Jeffrey Anshel, OD and Laura Stevens, M.Sci Square One Publishers 115 Herricks Road, Garden City Park, NY 11040 9780757004490, $17.95 PB, $9.95 Kindle, 288pp,