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A substance that will cause a clumping of particles such as bacteria or erythrocytes. Of major importance are the specific or immune agglutinins, which are antibodies that will agglutinate bacteria containing the corresponding antigens on their surfaces. Agglutinins are readily determined, and their presence is of diagnostic value to indicate present or past host contact with the microbial agent sufficient to result in antibody formation. See Agglutination reaction, Antibody

Analogous reactions involve erythrocytes and their corresponding antibodies, the hemagglutinins. Hemagglutinins to a variety of erthyrocytes occur in many normal sera, and their amounts may be increased by immunization. The blood group isoagglutinins of humans and animals are important special cases which must be considered in all proposed blood transfusions lest transfusion reactions result. See Blood groups

McGraw-Hill Concise Encyclopedia of Bioscience. © 2002 by The McGraw-Hill Companies, Inc.


An antibody from normal or immune serum that causes clumping of its complementary particulate antigen, such as bacteria or erythrocytes.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
In a five-year-old female patient who developed cold agglutinin disease after acute gastroenteritis, recovery could not be achieved with steroid and IVIG treatment and need for transfusion was eliminated following a single application of plasmapheresis (4).
(23) Mixed-type AIHA may be overdiagnosed because a warm autoantibody can elevate the titer of clinically insignificant cold autoantibodies (23) (though in these cases the cold agglutinin would tend to be evident only at the lower thermal amplitudes such as <30[degrees]C).
These foods include avocado, latex hevein, lemon and lime, orange juice (pasteurized and concentrate), cooked Brussels sprouts, baked white potato, seaweed, radish, roasted almond, raw and roasted Brazil nut, cashew, roasted cashew, cashew vicilin, raw and roasted macadamia nut, mustard seeds, roasted peanut, peanut butter, raw and roasted pistachio, soy bean agglutinin, gluten-free soy sauce, tofu, roasted sunflower seeds, gelatin, cooked egg yolk, raw salmon, cooked tilapia, raw tuna, cooked tuna, cooked clam, cooked scallops, cooked squid (calamari), cooked shrimp, cow's milk, casein (alpha and beta), sesame, hemp, rye, barley, kamut, buckwheat, sorghum, millet, spelt, amaranth, quinoa, yeast, oats, corn, and rice (see Table 2).
A mannose-specific lectin from onion (Allium cepa agglutinin, ACA) also showed mitogenic activity in murine thymocytes, as well as a high production of IFN[gamma] and IL-2.
In addition, bacteria can be identified by using samples that contain agglutinins to specific bacteria.
(h) Cold Agglutinin Disease (CAD) is an autoimmune disease characterised by the presence of high concentrations of circulating antibodies, usually IgM, dirested against red blood cells.
Diagnosis and treatment of cold agglutinin mediated autoimmune hemolytic anemia.
All patients received antibiotic therapy, until the serum agglutinins decreased to normal levels.
([dagger]) Assays conducted using 0.5% turkey red blood cells, 4 hemagglutinating units of virus, and sera treated with receptor- destroying enzyme, followed by adsorption with red blood cells if the serum sample contained nonspecific agglutinins. ([section]) Assays conducted using 100 tissue-culture infectious doses of virus and heat inactivated sera.