agglutinin

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Related to Agglutinins: Cold agglutinins

Agglutinin

A substance that will cause a clumping of particles such as bacteria or erythrocytes. Of major importance are the specific or immune agglutinins, which are antibodies that will agglutinate bacteria containing the corresponding antigens on their surfaces. Agglutinins are readily determined, and their presence is of diagnostic value to indicate present or past host contact with the microbial agent sufficient to result in antibody formation. See Agglutination reaction, Antibody

Analogous reactions involve erythrocytes and their corresponding antibodies, the hemagglutinins. Hemagglutinins to a variety of erthyrocytes occur in many normal sera, and their amounts may be increased by immunization. The blood group isoagglutinins of humans and animals are important special cases which must be considered in all proposed blood transfusions lest transfusion reactions result. See Blood groups

agglutinin

[ə′glüt·ən·ən]
(immunology)
An antibody from normal or immune serum that causes clumping of its complementary particulate antigen, such as bacteria or erythrocytes.
References in periodicals archive ?
Particles of an antigen will only clump together in the presence of the specific agglutinin to that antigen.
Key Words: Mycoplasma pneumoniae, hemolytic anemia, cold agglutinins, arterial thrombosis, pneumonia
Spurious thrombocytopenia due to EDTA-independent cold-reactive agglutinins.
The native agglutinins serve as specific adhesion contacts to fuse yeast cells of opposite mating type during mating.
While the maximal age at which this protocol may be used safely has yet to be determined, the investigators said, "the appropriate population could include all infants in whom [blood group] isohem agglutinins have not yet developed.
Previous studies have confirmed the presence of lysozyme- (McDade & Tripp, 1967a) and mucus-derived agglutinins (Fisher 1992) in oyster pallial fluid, suggesting an important role for this fluid in the overall microbial defense system.
Kit dosage, id-nacl/enzima, enzymatic test and cold agglutinins in card 6 microtubes containing gel in saline to reverse grouping abo system.
During his 3-week hospital stay, mycoplasmosis of the lung and a respiratory syncytial virus infection were diagnosed by the detection of high-titer Mycoplasma agglutinins in serum samples and positive test results for the presence of respiratory syncytial virus in nasopharyngeal secretions.
Further members of the class II RIPs are abrin and the two Ricinus communis agglutinins (RCA) I and II.
The persistence of leptospiral agglutinins titers in human sera diagnosed by the microscopic agglutination test.
Roeth and his colleagues investigated the potential effect of eculizumab therapy in one patient with CAD, a rare and severe disease characterized by the production of circulatory cold agglutinins, a type of monoclonal antibody that lead to hemolysis.
Although there was no consensus on the diagnostic titer for a single Widal test, all the studies reported a "positive" Widal test based on a fourfold rise in O agglutinins in repeated tests or a titer of 1:80 or greater in a single test (Table 1).