In a five-year-old female patient who developed cold agglutinin
disease after acute gastroenteritis, recovery could not be achieved with steroid and IVIG treatment and need for transfusion was eliminated following a single application of plasmapheresis (4).
23) Mixed-type AIHA may be overdiagnosed because a warm autoantibody can elevate the titer of clinically insignificant cold autoantibodies (23) (though in these cases the cold agglutinin
would tend to be evident only at the lower thermal amplitudes such as <30[degrees]C).
This patient's recent weight loss was concerning for underlying systemic disease, so a laboratory work-up including complete blood count, serum protein electrophoresis, cold agglutinins
, antinuclear antibody, rheumatoid factor, and cryoglobulins was performed.
activity in Pacific oyster (Crassostrea gigas) hemolymph following in vivo Vibrio anguillarum challenge.
Particles of an antigen will only clump together in the presence of the specific agglutinin
to that antigen.
Q When preheating a specimen with a severe cold agglutinin
does not work (i.
h) Cold Agglutinin
Disease (CAD) is an autoimmune disease characterised by the presence of high concentrations of circulating antibodies, usually IgM, dirested against red blood cells.
The clinical diagnosis of Mycoplasma pneumonia: the diagnostic importance of highly elevated serum cold agglutinins
A lipopolysaccharide binding agglutinin
isolated from brown shrimp (Penaeus californiensis Holmes) haemolymph.
Table 1 Lectins used in the study and their carbohydrate specificity Lectin Abbreviation Source Specificity Concanavalin ConA Canavalia Methyl agglutinin
ensiformis [alpha]v-mannopyranoside; D-Mannose; D-Glueose Pisum sativum PEA Pisum [alpha]-Methyl agglutinin
sativum [alpha]mannoside; [alpha]-Methyl glucoside Peanut PNA Arachis [alpha]-Lactose; D-Galactose: agglutinin
hypogaea N-Acetylgalactosimine Soybean SBA Glycine N-Acetylgalactosamine; agglutinin
maxima D-Galactose; Methyl [alpha]-D-galaclopyranoside Ulex europaeus UEA I Ulex L-Fucose agglutinin
europaeus Wheat germ WGA Triticum N-Acetylglucosamine agglutinin
Epidemiological survey on anti-leptospire agglutinins
in buffaloes from Vale do Ribeira (Brazil).
The serum was therefore, subjected to standard tube agglutination test (SAT--suspension of pure smooth culture of Brucella abortus strain 99 in phenol saline, IVRI, Izatnagar) to know the titre of brucella agglutinins