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Related to Agglutinins: Cold agglutinins


A substance that will cause a clumping of particles such as bacteria or erythrocytes. Of major importance are the specific or immune agglutinins, which are antibodies that will agglutinate bacteria containing the corresponding antigens on their surfaces. Agglutinins are readily determined, and their presence is of diagnostic value to indicate present or past host contact with the microbial agent sufficient to result in antibody formation. See Agglutination reaction, Antibody

Analogous reactions involve erythrocytes and their corresponding antibodies, the hemagglutinins. Hemagglutinins to a variety of erthyrocytes occur in many normal sera, and their amounts may be increased by immunization. The blood group isoagglutinins of humans and animals are important special cases which must be considered in all proposed blood transfusions lest transfusion reactions result. See Blood groups


An antibody from normal or immune serum that causes clumping of its complementary particulate antigen, such as bacteria or erythrocytes.
References in periodicals archive ?
In a five-year-old female patient who developed cold agglutinin disease after acute gastroenteritis, recovery could not be achieved with steroid and IVIG treatment and need for transfusion was eliminated following a single application of plasmapheresis (4).
23) Mixed-type AIHA may be overdiagnosed because a warm autoantibody can elevate the titer of clinically insignificant cold autoantibodies (23) (though in these cases the cold agglutinin would tend to be evident only at the lower thermal amplitudes such as <30[degrees]C).
This patient's recent weight loss was concerning for underlying systemic disease, so a laboratory work-up including complete blood count, serum protein electrophoresis, cold agglutinins, antinuclear antibody, rheumatoid factor, and cryoglobulins was performed.
Agglutinin activity in Pacific oyster (Crassostrea gigas) hemolymph following in vivo Vibrio anguillarum challenge.
Particles of an antigen will only clump together in the presence of the specific agglutinin to that antigen.
Q When preheating a specimen with a severe cold agglutinin does not work (i.
h) Cold Agglutinin Disease (CAD) is an autoimmune disease characterised by the presence of high concentrations of circulating antibodies, usually IgM, dirested against red blood cells.
The clinical diagnosis of Mycoplasma pneumonia: the diagnostic importance of highly elevated serum cold agglutinins.
A lipopolysaccharide binding agglutinin isolated from brown shrimp (Penaeus californiensis Holmes) haemolymph.
Table 1 Lectins used in the study and their carbohydrate specificity Lectin Abbreviation Source Specificity Concanavalin ConA Canavalia Methyl agglutinin ensiformis [alpha]v-mannopyranoside; D-Mannose; D-Glueose Pisum sativum PEA Pisum [alpha]-Methyl agglutinin sativum [alpha]mannoside; [alpha]-Methyl glucoside Peanut PNA Arachis [alpha]-Lactose; D-Galactose: agglutinin hypogaea N-Acetylgalactosimine Soybean SBA Glycine N-Acetylgalactosamine; agglutinin maxima D-Galactose; Methyl [alpha]-D-galaclopyranoside Ulex europaeus UEA I Ulex L-Fucose agglutinin europaeus Wheat germ WGA Triticum N-Acetylglucosamine agglutinin vulgaris
Epidemiological survey on anti-leptospire agglutinins in buffaloes from Vale do Ribeira (Brazil).
The serum was therefore, subjected to standard tube agglutination test (SAT--suspension of pure smooth culture of Brucella abortus strain 99 in phenol saline, IVRI, Izatnagar) to know the titre of brucella agglutinins.