The latency between previous cancer treatment and leukemia development is longer after alkylating agents
(3-8 years) and shorter after topoisomerase II inhibitors (2-3 years).
This would include patients diagnosed with cancers known to require exposure to known gonadotoxic agents (such as high doses of alkylating agents
, as seen in cases of rhabdomyosarcoma, Ewing's sarcoma, neuroblastoma, Hodgkin's lymphoma) or radiation to achieve cure (e.
25) However, both alkylating agents
are associated with serious side effects such as anaemia, teratogenicity, thrombocytopenia, infertility, infection, and in the case of cyclophosphamide, the development of secondary malignancies.
Antimetabolites, T-Cell Inhibitors and Alkylating Agents
Radiotherapy, alkylating agents
, and risk of bone cancer after childhood cancer," Journal of the National Cancer Institute, vol.
The major medications used for chemotherapy include various combinations of the following agents: the immunomodulators thalidomide and lenalidomide; the proteasome inhibitor bortezomib; the alkylating agents
melphalan and cyclophosphamide; and the steroids dexamethasone and prednisone.
This is especially true for women who may be receiving gonadotoxic therapies, such as alkylating agents
or abdominal/pelvic radiation.
He begins with the reagents and processes: alkylating agents
, acylating agents, nitration and nitrosylation, oxidation, and modifying proteins with reducing agents.
It was reported yesterday that the contract has been signed to develop structurally new generation alkylating agents
to treat haematological malignancies.
Our study showed that these alkylating agents
are present at levels sufficient to cause DNA damage and could potentially have adverse implications to human health, particularly in the case of the development of oral cancer for BQ chewers," they said.
reported that patients treated with alkylating agents
had fewer primordial follicles in their ovaries than those that were not treated with these agents (8).
In general the alkylating agents
interact with DNA, preventing replication and/or transcription.