, including terbinafine and naftifine (available in 1% creams or 1% solutions), provide cure rates of > 75% and require only once-daily application for shorter periods.
12-14) It is a member of a new class of antifungal agents, the allylamines
, which have a different mechanism of action (squalene epoxidase inhibitor) than the azoles have.
As per the existing literatures, antifungal drugs have been classified into three classes of natural products (griseofulvin, polyenes and echinocandins) and four classes of synthetic drugs (azoles, allylamines
, phenylmorpholines and flucytosine) having clinical value against mycotic infections.
Patents granted include composition of matter claims for topical formulations of antifungal allylamines
(including terbinafine), as well as methods of treatment claims for treating onychomycosis using these novel formulations, enabling enhanced penetration of antifungal allylamines
into and through the nail.
Rather than affecting P450 and lanosterol-converting enzymes, the allylamines
inhibit squalene oxidase, resulting in lethal fungal cell membrane changes.
Moreover, the antifungal drugs available to successfully treat these infections are becoming increasingly limited, with polyenes, allylamines
, azoles (e.
Inhibition of squalene epoxidase by allylamines
results in sterol deficiency in the fungal cell wall and also intracellular accumulation of squalene and finally fungal cell death.
may be more effective than topical azoles for tinea corporis (4) (strength of recommendation [SOR]: A).
A review of randomised control studies found allylamines
were effective in curing fungal infections and produced a faster response than azoles but cure rates were similar.
Antifungal dermatologic agents: Azoles and allylamines
Topical agents used in these infections are the imidazoles, allylamines
, tolnaftate and ciclopirox.
GII) is pleased to announce a new market research report, “Antifungals Market to 2017 - Generic Erosion of Major Polyenes, Azoles, Allylamines
and Echinocandins to Slow Value Growth” by GBI Research.