Estradiol

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estradiol

[‚es·trə′dī‚ȯl]
(biochemistry)
C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.

Estradiol

 

C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

References in periodicals archive ?
Selina, from Comber, Co Down, said: "Alora's condition means we can need emergency support at any time and ambulance crews have always been so professional when we have to call in an emergency.
"Los Angeles County Homicide Bureau is requesting the public's assistance in locating Alora and safely returning her to her family.
Container vessel, SM New Yark sailed out to sea on Friday morning, while five more ships CMA CGM Almaviva, Hong Harvest, African Avocet, Alister Bay and Alora are expected to sail on the same day in the afternoon.
Findings by our correspondent indicated that the hostility, which began on Wednesday between members of Aye and Alora cult groups spilt over to Thursday as dangerous weapons such as guns, axes and machetes were freely used during the violent clashes.
Fraser-Smith explains: "We're re-branding that as Alora ristorante so it's going be about big bowls of pasta, salads, pizzas and carafes of wine.
Alora is from 2013 and has been plagued with strange blackouts after which she wakes up with no idea of how she got there.
- sister-inlaw Joy'o xxx GALE Arthur Loving brother and best friend to Ralph, loved brother-in-law of Mavis, cherished uncle to Neil, Helen and Helen, greatuncle to Jessica, Samuel, Alora and Indy.
Alora, a chemical products tanker operated by Graypen carrying soya bean oil from the Netherlands.
(Howard) Koza of Oxford; one sister, Suzanne Berube of Douglas; a nephew, Aiden and a niece, Alora; many aunts, uncles and cousins.
A woman in her 80s died early Friday when a river breached its banks and floodwater swept past her home in Alora, north of Malaga, a regional government spokesman told AFP.
The elderly woman was killed when flood water entered her home in Alora near Malaga.