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A hereditary form of hemolytic anemia resulting from a defective synthesis of hemoglobin: thalassemia major is the homozygous state accompanied by clinical illness, and thalassemia minor is the heterozygous state and may not have evident clinical manifestations. Also known as Mediterranean anemia.



(also thalassanemia), a familial hemolytic anemia, first detected in 1925 among inhabitants of the Mediterranean region. Thalassemia is caused by disturbances in hemoglobin synthesis.

References in periodicals archive ?
If two of the four loci are affected, the condition is called alpha thalassemia trait with mild microcytic hypochromic anemia.
We are observing a lot of uncertain couples with alpha thalassemia in premarital screening tests in hemoglobinopathy diagnosis center of in Antalya, it needs molecular diagnostic test to all of them.
The most common ones are alpha thalassemia and beta thalassemia.
The most common types of thalassemia are alpha thalassemia and beta thalassemia.
The evaluation of patients for alpha thalassemia carrier status is complicated by the fact that there are two different functional alpha globin genes--alpha 1 and alpha 2.