is caused by mutations in the alpha globin gene locus on chromosome 16.
Conclusion: Alpha thalassemia
deletions (-a3.7, -a4.2) are the common co-inherited deletions found in beta thalassemia major patients.
Molecular studies in different regions of Brazil show an approximately 25% prevalence of alpha thalassemia
in Brazilian populations (LERMEN, 2007).
DNA samples were obtained from all members of the family and polymerase chain reaction (PCR) was performed according to the protocol described by Baysal and Huisman3 for the detection of -a3.7, -a4.2, and -MED mutations as common alpha thalassemia
gene mutations in Iran.5
; prevalence and hematologic findings in American blacks.
SYMPTOMS: The most severe form of alpha thalassemia
major causes stillbirth (death of the unborn baby during birth or the late stages of pregnancy).
Thalassemia can be divided into different types mainly "Alpha Thalassemia
" and "Beta Thalassemia" depending on the defective location, whether it is in the gene responsible for producing the protein series of Alpha or Beta in the hemoglobin.
The patented test detects Alpha Thalassemia
mutations and their use as predictors of blood-related disorders.
Molecular mechanisms of alpha thalassemia
. In: Steinberg MH, Forget BG, Higgs DR, Nagel RL, eds.
# In the worst cases of Thalassemia, where a patient is diagnosed with Alpha Thalassemia
Major (all four of the alpha globin genes are abnormal or missing), some patients may not survive past childhood.
The example of hemoglobin Constant Spring comes to mind, often facetiously referred to in our laboratory as "Small Bump Disease." Positive identification of the presence of Constant Spring is critical in that it can be a severe form of alpha thalassemia
and a predictor of potential hemoglobin H disease in the future.
Most common disorders Commenting on the most common genetic blood disorders, Al Kindi said, "According to the studies carried out by the Ministry of Health in 1995 and also studies done by us in 2010, 5.7 per cent of the population is affected by sickle cell, and around 2.2 or 2.6 per cent is affected by Beta thalassemia." Alpha thalassemia
is the most common disease which affects up to 48 per cent of the population, said Al Kindi, who is also a founding member of Oman Hereditary Blood Disorder Association (OHBDA).