Positive expression result showed that the tumor originated from pancreatic alpha cells
. In addition, we were performed staining for carcinoembryonic antigen and Ki-67 protein.
In younger age group, the alcoholism increased the blood glucose level by increasing the appetite as well as by stimulating the alpha cells
Failure to suppress glucagon secretion from the alpha cells
of the pancreas contributes to hyperglycaemia.
Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells
triggers glucagon secretion.
Within the constraints imposed by the depth of proteome coverage, I could thus study the relative molar abundances of core functional pathways within human beta cell preparations and directly compare these to rat beta and alpha cells
. I found that the expression levels of core functional pathways (intermediary metabolism, protein synthesis, signaling, and cytoskeleton) were well conserved but also discovered interesting differences, particularly in enzymes of nutrient metabolism and antioxidant defenses.
This latter finding is likely a consequence of GLP-1--based therapies' suppression of the release of glucagon by alpha cells
, since decreasing the availability or action of the hormone glucagon has been shown in a variety of prior studies to induce a proliferation of pancreatic alpha cells
The total number of cells per islet section and the beta and alpha cells
were counted as they differentially stained with chrome alum Hematoxylin-phloxin.
The two main types of pancreatic cells are alpha cells
and beta cells.
in the pancreas can spontaneously transform into insulin-producing beta cells, researchers report online April 4 in Nature.
"People without diabetes can control blood glucose levels so tightly because we have both beta and alpha cells
working on it.
This supports our hypothesis that the antihyperglycaemic effect of stevioside is primarily due to a direct action on the insulin producing beta cells and glucagon producing alpha cells
. In addition, it has been suggested that stevioside inhibits phosphorylation in the rat liver mitochondrias that may be attributed to an inhibition of the ADP/ATP exchange.
Pancreatic endocrine cells include all hormoneproducing cells, such as insulin-producing beta cells and glucagon-producing alpha cells
, within the islet of Langerhans, whereas the duct cells are epithelial cells that line the ducts of the pancreas.