lipoic acid

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lipoic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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Lipoic Acid


6,8-epi-dithio-octanoic acid, a widespread naturally occurring coenzyme, related to enzymes of the class of oxidoreductases. It exists in the form of crystals with melting point 59°-60°C and was first isolated from bull’s liver in 1941 (30 mg of lipoic acid was obtained from 10 tons of liver).

Lipoic acid participates in the transfer of acyl groups (acid radicals) and in biological oxidation reactions (for example, oxidative decarboxylation of pyruvic and ketoglutaric acids for conversion into acetyl-CoA and succinyl-CoA, respectively, with liberation of carbon dioxide). The oxidized form of lipoic acid is transformed into a reduced form, which is then reconverted into the oxidized form upon action of a specific enzyme:

Lipoic acid is the growth factor (vitamin) in certain microorganisms; it exists in composite protein form in the cells of plant and animal tissues.

lipoic acid

[lī′pō·ik ′as·əd]
C8H14O2S2 A compound which participates in the enzymatic oxidative decarboxylation of α-keto acids in a stage between thiamine pyrophosphate and coenzyme A.
References in periodicals archive ?
TABLE Consider these alternatives for neuropathic pain (2-12] Intervention Dose Adverse effects/special considerations Acetyl-L-carnitine 2000-3000 mg/d Nausea, vomiting; urine, breath, and sweat may have fishy odor Avoid use in patients taking warfarin Alpha lipoic acid 600 mg/d Nausea, vomiting, skin rash Possible injection site reaction with IV administration ALA/Rx combination ALA 100 mg bid + Nausea, vomiting pregabalin 75 mg bid + methylcobalamin 750 meg bid B vitamins Benfotiamine 100 mg qid Nausea, vomiting OR B1 25 mg OR benfotiamine 320 mg + B6 50-720 mg + B121000 meg/d OR L-methylfolate 3 mg + pyridoxal 5-phosphate 35 mg + methylcobalamin 2 mg bid Capsaicin Topical 0.
Protective effects of alpha lipoic acid on carbon tetrachloride-induced liver and kidney damage in rats.
Alpha lipoic acid is synthesized in vitro as a racemic d,l mixture.
At BioLink we are actively developing alpha lipoic acid for clinical indications that are independent of InVasc's interests, and InVasc's work actually will help support the development of our products.
Alpha lipoic acid possess dual antioxidant and lipid lowering properties in atherosclerotic-induced New Zealand White rabbit.
Alpha lipoic acid protects lens from H(2)0(2)-induced cataract by inhibiting apoptosis of lens epithelial cells and inducing activation of anti-oxidative enzymes.
Meanwhile, alpha lipoic acid is an antioxidant that helps reduce the free radicals that lead to skin's aging.
The alpha lipoic acid and alpha hydroxy acid work to minimise enlarged pores while reducing the appearance of fine lines and wrinkles.
You can safely take 100 mg a day of alpha lipoic acid.
Tenders are invited for Benfotiamine Plus Methylcobalamin Plus Alpha Lipoic Acid Plus Inositol Plus Chromium Polyniconate Plus Pyridoxime Hydrochloride Plus Folic Acid Tablet/Capsule.
The Journal of Alzheimer's Disease published the outcome of a recent trial conducted by researchers at Oregon Health & Science University in Portland, which revealed that supplementation with omega-3 fatty acids and alpha lipoic acid slowed functional and cognitive decline in Alzheimer's disease patients.
Alpha lipoic acid (ALA) is a naturally occurring shortchain fatty acid with a powerful antioxidant capacity, which widely exists in foods (Packer et al.