lipoic acid

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lipoic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Lipoic Acid


6,8-epi-dithio-octanoic acid, a widespread naturally occurring coenzyme, related to enzymes of the class of oxidoreductases. It exists in the form of crystals with melting point 59°-60°C and was first isolated from bull’s liver in 1941 (30 mg of lipoic acid was obtained from 10 tons of liver).

Lipoic acid participates in the transfer of acyl groups (acid radicals) and in biological oxidation reactions (for example, oxidative decarboxylation of pyruvic and ketoglutaric acids for conversion into acetyl-CoA and succinyl-CoA, respectively, with liberation of carbon dioxide). The oxidized form of lipoic acid is transformed into a reduced form, which is then reconverted into the oxidized form upon action of a specific enzyme:

Lipoic acid is the growth factor (vitamin) in certain microorganisms; it exists in composite protein form in the cells of plant and animal tissues.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

lipoic acid

[lī′pō·ik ′as·əd]
C8H14O2S2 A compound which participates in the enzymatic oxidative decarboxylation of α-keto acids in a stage between thiamine pyrophosphate and coenzyme A.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Protective effects of alpha lipoic acid on carbon tetrachloride-induced liver and kidney damage in rats.
Now, Alpha Lipoic Acid will always be in our cupboard whether hubby is working or not.
3 Alpha lipoic acid and its reduced metabolic product dihydrolipoic acid (DHLA) both inhibited formation of beta-amyloid fibrils from beta-amyloid protein in vitro.
The purpose of this commentary is to evaluate the benefits of intravenous magnesium and alpha lipoic acid in order to evaluate whether more chiropractors should perform intravenous infusions as adjunct therapy to spinal manipulation.
The institute could also provide more advanced wellness profile that could determine one's level of antioxidants (Vitamin A, carotene, Vitamin C, Vitamin D, Vitamin E, alpha lipoic acid, and CoQ10); B complex (Vitamins B1, B2, B3, B6, B7, B9 and B12); minerals (manganese, magnesium, zinc and molybdenum); amino acids (20 essential and nonessential amino acids); fatty acid metabolites; malabsorption and dysbiosis markers; and toxin and detoxification markers.
One small, double- blinded, placebo-controlled 12-month study published in 2014 in the Journal of Alzheimer's Disease found that the combination of fish oil (975 mg of EPA and 675 mg of DHA) and 600 mg of alpha lipoic acid slowed both cognitive and functional decline in people with dementia."
This acid category includes ferulic acid, azelaic acid, retinoic acid and alpha lipoic acid. Ferulic acid is used for making new collagen in skin and stopping free radical damage.
In streptozotocin-induced rats, it may be assumed that alpha lipoic acid treatment can protect against impaired vascular responsiveness [12].
Neurofuse's top tier proprietary blend has nootropic ingredients like Alpha Lipoic Acid, Bacopa Monnieri, Huperzine A, and Vinpocetine.
11 January 2012 - China Nuokang Bio-Pharmaceutical Inc (NASDAQ:NKBP) said today it had agreed to acquire the manufacturing licence and marketing rights for Alpha Lipoic Acid Capsule (ALA), an antioxidant product for the treatment of diabetic neuropathy, from Shandong Qidu Pharmaceutical for CNY18m (USD3m/EUR2.2m).
For women, two other important nutrients worth considering are chromium and alpha lipoic acid. Both have been found to be beneficial in cases of insulin resistance, a common feature of infertility due to polycystic ovarian syndrome (PCOS).
WIN CoQ10 also now contains alpha lipoic acid to help extend CoQ10's energy production benefits.