In contrast to sulfonylureas and biguanides, alpha-glucosidase inhibitors
do not lower fasting glucose levels.
TABLE 1 How these antidiabetic drugs affect weight (3) Weight gain Weight neutral Weight loss Insulin Alpha-glucosidase inhibitors
GLP-1 agonists Meglitinides Bromocriptine Metformin Sulfonylureas Colesevelam Pramlintide Thiazolidinediones DPP-4 inhibitors SGLT2 inhibitors DPP-4, dipeptidyl peptidase-4; GLP-1, glucagon-like peptide-1; SGLT2, sodium-glucose co-transporter 2.
(miglitol, Glyset[R]; ascarbose, Precose[R]) produce their glucose lowering effect by slowing the absorption of carbohydrate from the upper gastrointestinal (GI) tract.
Possible combinations with sulfonylurea drugs, alpha-glucosidase inhibitors
and biguanide drugs can be foreseen.
(AL-fa gloo-KOS-ih-dayss in-HIB-it-ers).
According to the metabolic fulcrum-based, strategy, insulin and insulin secretagogues are preferred in patients with predominant insulin deficiency (catabolism), dipeptidyl peptidase 4 inhibitors (DPP4i) and alpha-glucosidase inhibitors
(AGIs) find utility in eubolic type 2 diabetes, while glucagon- like peptide 1 receptor agonists (GLP1RA) and sodium glucose cotransporter 2 inhibitors (SGLT2i) are strongly indicated in those with predominant insulin resistance (maladaptive anabolism).
for people with impaired glucose tolerance or impaired fasting blood glucose.
Available oral agents include insulinotropic agents (sulfonylureas and meglitinides), biguanides, alpha-glucosidase inhibitors
, and thiazolidinediones (glitazones).
According to the National Diabetes Information Clearinghouse (a federal agency), five major classes of diabetes drugs are on the market: sulfonylureas, biguanides, alpha-glucosidase inhibitors
, thiazolidinediones and meglitinides.
Find Your Diabetes Medicines(*) Sulfonylureas Amaryl DiaBeta Diabinese Dymelor Glucotrol Glucotrol XL Glynase PresTab Micronase Orinase Tolinase Biguanides Glucophage Alpha-glucosidase Inhibitors
Glyset Precose Thiazolidinediones Rezulin Meglitinides: Prandin Insulins Lispro (Humalog) Regular Premixed Ultralente NPH or Lente
7 However, they, along with sodium glucose co-transporter (SGLT) 2 inhibitors, pioglitazone and alpha-glucosidase inhibitors
, are able to reduce blood pressure significantly.