In this project the MC fellow will exploit some novel technology under development in the lab of the supervisor to develop thermostable alpha-keto acid
decarboxylases, which are not typically present in thermophiles.
Amino acid synthesis depends on the formation of the appropriate alpha-keto acid
, which is then transaminated to form an amino acid (Guyton and Hall, 2006).
17) R-lipoic acid or its reduced form, DHLA, is located in mitochondrial membranes where it serves as an important coenzyme in alpha-keto acid